The significance of the oxidative stress markers in the one-year prognosis of patients with acute ischemic stroke: a case-control study

BMC Neurology

Sheida Shaafi¹  Mohammad Khalili²  Fina Hadisi³  Seyed Aria Nejadghaderi⁴  Mahsa Mahmoudinezhad⁵  Hamidreza Razmi⁶ 

[1] Department of Neurology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;Multiple Sclerosis Research Center, Neuroscience institute, Tehran University of Medical Sciences, Tehran, Iran;Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;School of Medicine, Shahid Beheshti, University of Medical Sciences, Tehran, Iran;Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Tehran, Iran;Student Research Committee, Department of Community Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran;Student Research Committee, Department of Nutrition, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Stroke;    Total antioxidant capacity;    Malondialdehyde;    Modified Rankin scale;    National Institutes of Health stroke scale;    Case-control study;   

DOI  :  10.1186/s12883-021-02257-x

来源: Springer

【 摘 要 】

BackgroundStroke is a major cause of mortality and morbidity. Also, free radicals and oxidative stress are deleterious factor in the stroke progression. We aimed to evaluate the association between oxidative stress markers and odds of having risk factor for stroke or developing stroke.MethodsThe present case-control study was conducted on 556 participants in Imam-Reza hospital, Tabriz, Iran. Subjects were divided into three group, including individuals with acute ischemic stroke, those who were at risk of stroke, and healthy controls. All enrolled participants except for controls underwent neurological examinations and brain magnetic resonance imaging (MRI). Stroke-related disability and stroke severity were evaluated by modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS), respectively. Serum malondialdehyde (MDA) level and total antioxidant capacity (TAC) were measured within 48 h of the initiation of stroke. One-way ANOVA and Chi-square tests were used for comparing characteristics between groups. Multivariable logistic regression was implemented for odds of stroke based on MDA and TAC quartiles. Also, Spearman’s correlation was utilized.ResultsSerum MDA, systolic and diastolic blood pressure, cholesterol, and triglyceride were significantly higher in the stroke group than controls. High levels of MDA were associated with increased development of stroke (P-value < 0.001), however TAC and MDA were not associated with having risk factors for stroke (P-value = 1.00 and 0.27, respectively). Also, TAC level was negatively associated with baseline (ρ = − 0.28; P-value = 0.04) and follow-up (ρ = − 0.31; P-value = 0.03) NIHSS scores. Moreover, MDA was correlated with mRS score at follow-up (ρ = − 0.26; P-value = 0.04).ConclusionsThe balance between antioxidants and oxidants markers might reveal a new approach in this context. Further studies are warranted to identify the source of oxidative stress as well as cessation of the production of oxygen radicals in stroke.

【 授权许可】

CC BY