Anti-cancer properties of quercetin in osteosarcoma

Cancer Cell International

Fatemeh Sadoughi¹  Zatollah Asemi¹  Parisa Maleki Dana¹  Bahman Yousefi² 

[1] Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, I.R. of Iran;Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran;Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran;

关键词: Quercetin;    Osteosarcoma;    Apoptosis;    Proliferation;    Cell viability;   

DOI  :  10.1186/s12935-021-02067-8

来源: Springer

【 摘 要 】

Osteosarcoma is a primary bone tumor. Although it is a rare disease in general, it is the most common primary bone tumor among children. Despite the significant advances made in the field of osteosarcoma treatment, the outcomes of this disease are still unfavorable. Besides, there is still no targeted therapy for osteosarcoma that can be used in clinical settings. Quercetin is a member of the phytochemical family which is used for different diseases including cardiovascular diseases, diabetes, and cancer. Its anti-cancer effects are examined in many types of cancer including breast, colon, lung, prostate, and pancreatic cancers and have shown promising results. Herein, the studies dealing with the antitumor roles of quercetin in osteosarcoma are reviewed in this article. We take a look into quercetin’s ability to affect proliferation, apoptosis, invasion, and chemo-resistance of the osteosarcoma cells through regulating protein expression and signaling pathways.

【 授权许可】

CC BY