Molecular evolution of the ATP-binding cassette subfamily G member 2 gene subfamily and its paralogs in birds

BMC Evolutionary Biology

article

Ma, Shengchao¹  Hua, He¹  Liu, Hehe¹  Sun, Wenqiang¹  Mustafa, Ahsan²  Xi, Yang¹  Pu, Fajun¹  Li, Yanying¹  Han, Chunchun¹  Bai, Lili¹ 

[1] Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University;Institute of Animal Nutrition, Key Laboratory for Animal Disease-Resistance Nutrition of China, Ministry of Education, Sichuan Agricultural University

关键词: Birds;    ABCG2;    ABCG2-like;    Gene duplication;    Gene family evolution;    Phylogeny;    Selection pressures;    Chromosomal synteny;   

DOI  :  10.1186/s12862-020-01654-z

学科分类：护理学

来源: BioMed Central

【 摘 要 】

ATP-binding cassette (ABC) transporters are involved in the active transportation of various endogenous or exogenous substances. Two ABCG2 gene subfamily members have been identified in birds. A detailed comparative study of the ABCG2 and ABCG2-like genes aid our understanding of their evolutionary history at the molecular level and provide a theoretical reference for studying the specific functions of ABCG2 and ABCG2-like genes in birds. We first identified 77 ABCG2/ABCG2-like gene sequences in the genomes of 41 birds. Further analysis showed that both the nucleic acid and amino acid sequences of ABCG2 and ABCG2-like genes were highly conserved and exhibited high homology in birds. However, significant differences in the N-terminal structure were found between the ABCG2 and ABCG2-like amino acid sequences. A selective pressure analysis showed that the ABCG2 and ABCG2-like genes were affected by purifying selection during the process of bird evolution. We believe that multiple members of the ABCG2 gene subfamily exist on chromosome 4 in the ancestors of birds. Over the long course of evolution, only the ABCG2 gene was retained on chromosome 4 in birds. The ABCG2-like gene on chromosome 6 might have originated from chromosome replication or fusion. The structural differences between the N terminus of ABCG2 protein and those of ABCG2-like proteins might lead to functional differences between the corresponding genes.

【 授权许可】

CC BY|CC0