Invasive Stratified Mucin-Producing Carcinoma (ISMC) of the uterine cervix: An analysis of 6 cases with distinctive clinicopathological features

Biocell

article

TING LAN¹  SHENG QIN¹  XIAOJIN GONG¹  PING ZHENG¹  JIAXIN YAN¹  YANG LIU¹ 

[1] Department of Pathology, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Cancer Hospital affiliate to School of Medicine

关键词: Invasive stratified mucin-producing carcinoma;    ISMC;    Stratified mucin-producing intraepithelial lesion;    SMILE;    Cervical carcinoma;    Human papillomavirus;   

DOI  :  10.32604/biocell.2021.015923

学科分类：仪器

来源: Biocell

【 摘 要 】

Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the stratified mucin-producing intraepithelial lesion (SMILE). ISMC can display variable architectural patterns and usually coexists with other more conventional types of HPV-associated carcinomas, which makes diagnosis and differential diagnosis of ISMC is difficult for pathologists. Moreover, the prognosis of ISMC is still controversial. We analyzed 6 ISMCs with detailed pathological and clinical information. Intraepithelial lesion, including 1 high-grade squamous intraepithelial lesion and 1 SMILE, was found. Various architectures were observed (including nest, glandular, solid, trabecular, and single cell). Nuclear peripheral palisading, apoptotic bodies and mitoses, and variable cytoplasmic mucin vacuoles were seen in all of our cases. The predominance of neutrophils infiltration was seen in only 1 tumor. All the tumors infiltrated the cervical stroma in Silva pattern C manner. p63 and/or p40 was characteristically expressed in the peripheral cells in only 2 cases. High-risk HPV infection was observed in 3/3 detected cases. All the patients were alive during the follow-up time. Recognition of this infrequent tumor may help pathologists and oncologists for an accurate diagnosis and a better understanding of the clinicopathological behavior.

【 授权许可】

CC BY