Occupational exposure to antineoplastic drugs in hospital environments: potential risk associated with contact with cyclophosphamide- and ifosfamide-contaminated surfaces

Medycyna Pracy

article

Nicola Mucci¹  Stefano Dugheri²  Andrea Farioli†³  Giacomo Garzaro⁴  Venerando Rapisarda⁵  Marcello Campagna⁶  Alessandro Bonari¹  Giulio Arcangeli¹ 

[1] University of Florence, Italy Department of Experimental and Clinical Medicine;Careggi University Hospital, Italy Industrial Hygiene and Toxicology Laboratory, Occupational Medicine Unit;University of Bologna, Italy Department of Medical and Surgical Sciences;University of Turin, Italy Department of Public Health and Pediatric Sciences;University of Catania, Italy Department of Clinical and Experimental Medicine;University of Cagliari, Italy Department of Medical Sciences and Public Health

关键词: occupational exposure;    cyclophosphamide;    antineoplastic drugs;    ifosfamide;    wipe test;    surface contamination;   

DOI  :  10.13075/mp.5893.00931

学科分类：内科医学

来源: Panstwowy Zaklad Wydawnictw Lakarskich

【 摘 要 】

Background: Cyclophosphamide (CP) and ifosfamide (IP) contaminations have been detected in hospital environments. This study was conducted to determine if there was any contamination in the spaces (floors and door handles) between the hospital exit and the antineoplastic drugs (ADs) preparation and administration units. At the same time, the authors proposed a new automation of the analytical procedure to considerably decrease the time needed for sample preparation and analysis. Material and Methods: To evaluate the ADs contamination of surfaces, 829 wipe tests were performed in a campaign involving 3 hospitals located in Italy. Sampling was performed using an innovative kit. The levels of ADs were measured in each wipe sample using liquid chromatography/triple quadrupole. Results: On-line solid-phase extraction guarantees the construction of a robust and reproducible analytical method. The CP and IP recoveries from stainless steel, polycarbonate and polyvinyl chloride ranged >80%, and the wipe holders and the automation tested ensured desorption efficiencies close to 100% for both the ADs. Of the 552 wipes taken on the spaces between the hospital exit and the preparation, administration and pharmacy warehouse units, 22 were greater than or equal to the limit of quantification, all adjacent to the administration units. Conclusions: This study provides an insight into the exposure situation against ADs residues. In order to improve environmental monitoring programs, the authors propose to evaluate the ADs contamination also outside the preparation, administration and pharmacy warehouse units.

【 授权许可】

CC BY-NC