Corrected QT interval and QT dispersion in temporal lobe epilepsy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

article

Nasef, Maram Samy¹  Gaber, Ahmed Abdelmonem²  Abdelhamid, Yousry Aboelnaga²  Bastawy, Islam³  Abdelhady, Salem Taha²  Wahid el din, Mona Mokhtar² 

[1] Faculty of Medicine, Cairo University;Neurology Department, Faculty of Medicine, Ain Shams University;Cardiology Department, Faculty of Medicine, Ain Shams University

关键词: Epilepsy;    Temporal lobe;    Corrected QT interval;    QT dispersion;    Arrhythmia;    Sudden cardiac death;   

DOI  :  10.1186/s41983-020-00257-1

学科分类：医学（综合）

来源: Springer

【 摘 要 】

Cardiac arrhythmias are expected among patients with epilepsy due to the effect of anti-epileptic drugs. Temporal lobe epilepsy also causes autonomic seizures that may affect heart rhythm. Prolongation of the corrected QT interval and QT dispersion is a risk factor for cardiac arrhythmia. We aimed to assess corrected QT interval and QT dispersion in patients with epilepsy and if there is a difference between patients with temporal epilepsy versus non-temporal epilepsy. This study was conducted on 100 patients (50 patients with temporal epilepsy and 50 patients with non-temporal epilepsy) and 50 age- and sex-matched healthy controls. They underwent a prolonged (6 to 24 h) 22 channel computerized electroencephalogram monitor with a 10–20 system. QT dispersion, QT interval, and corrected QT interval (using Bazett’s formula) were calculated. This study showed significantly higher QT dispersion and corrected QT interval in patients with epilepsy when compared to the age- and sex-matched control group (P < 0.001, P < 0.001). Also, the corrected QT interval and QT dispersion were significantly higher in temporal epilepsy patients when compared to the non-temporal group (P < 0.001, P < 0.001). Corrected QT interval and QT dispersion are higher in epileptic patients and more among temporal epilepsy patients in comparison to non-temporal epilepsy patients.

【 授权许可】

CC BY