Essential tremor: what is beyond the oscillatory monosymptomatic illness?

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

article

Elhassanien, Mahmoud Ebrahim Mostafa¹  ELAhwal, Shereen Ahmed²  Rashed, Khaled Hussein¹  Bahnasy, Wafik Said¹  El-Heneedy, Yasser Abo Elfotoh¹  El-Seidy, Ehab Ahmed Shawky¹  Tomoum, Mohamed Osama¹  Ramadan, Kareem Mohammed¹  Kotait, Mona Ahmed¹  Amer, Reham Abdel Rahman¹ 

[1] Faculty of Medicine, Tanta University;Tanta University Hospitals

关键词: Essential tremors;    Sniffin’ sticks test;    Posturography;    Mismatch negativity;    DTI;   

DOI  :  10.1186/s41983-020-00200-4

学科分类：医学（综合）

来源: Springer

【 摘 要 】

Essential tremor (ET) is now considered as a slowly progressive neurodegenerative disorder with a variety of motor and non-motor manifestations. The objectives of this work were to study the existence of cognitive, mood, olfactory, and balance dysfunctions in ET patients and their relation to tremor severity as well as patients’ activity of daily livings. This study was performed on 36 ET patients and 24 healthy controls subjects (HCS) submitted to The Essential Tremor Rating Assessment Scale (TETRAS), advanced activity of daily living scale (AADLs), Montreal cognitive assessment scale (MoCA), Montgomery–Åsberg Depression Rating Scale (MADRS), auditory mismatch negativity (MMN), Sniffin’ Sticks test (SST), computerized dynamic posturography (CDP), and brain MRI diffusion tensor tractography (DTT). ET patients showed significant decrease in AADLs, MoCA, SST (threshold, identification, and discrimination subscales) as well as visual and vestibular ratios of CDP compared to HCS. Auditory MMN showed significant reduction in the amplitude and prolongation of latencies while corticospinal tracts, thalamo-cortical connectivity, and middle cerebellar peduncles DTT revealed reduced fractional anisotropy in ET patients with normal tracts densities. ET patients exhibit a wide variety of non-motor manifestations including cognitive impairment, depressive symptoms, hyposmia, and increased risk of falls with consecutive reduced activity of daily living beyond the deleterious effects of the kinetic tremor.

【 授权许可】

CC BY