Exhaled breath diagnostics of lung and gastric cancers in China using nanosensors

Cancer Communications

article

Alaa Gharra¹  Jianming Huang³  Zhuoqi Xuan³  Bing Huang⁴  Song Wu⁴  Yana Milyutin¹  Viki Kloper-Weidenfeld¹  Hossam Haick¹  Yoav Y. Broza¹  Guiping Yu⁴  Weidong Mao⁵  Dong Shen⁵  Lichun Deng⁵  Chun Wu⁵  Qiong Wang⁵  Xia Sun⁵ 

[1] Department of Chemical Engineering and Russell Berrie Nanotechnology Institute, Technion – Israel Institute of Technology;These authors contributed equally to the work;Department of Gastrointestinal Surgery, Jiangyin Hospital Affiliated to Southeast University Medical College;Department of Chest Surgery, Jiangyin Hospital Affiliated to Southeast University Medical College;Department of Oncology, Jiangyin Hospital Affiliated to Southeast University Medical College

关键词: Sensor;    Breath;    Volatile Organic Compound;    Diagnosis;    Lung Cancer;    Gastric Cancer;   

DOI  :  10.1002/cac2.12030

学科分类：社会科学、人文和艺术（综合）

来源: Springer

【 摘 要 】

Breath analysis is a promising diagnostic approach for various conditions [1, 2]. It is based on the identification of volatile organic compounds (VOCs) emitted in the breath, which creates a unique volatolomic signature [3]. Owing to their characteristics, VOCs can be measured non-intrusively from the breath or other body sources [3, 4]. Several studies have shown the diagnostic potential for a variety of conditions based on VOC analysis [5-9]. Malignant diseases, where early detection is crucial, are the main focus of VOC analysis, with lung cancer (LC) and gastric cancer (GC) being the most studied. LC and GC together were responsible for approximately 2.5 million deaths globally in 2018 [10]. The aim of VOC analysis of the breath using sensors is to identify a “VOC-print” comprising the total abundances and ratios of the compounds in the breath, giving an overall unique chemical pattern [11]. This technology can help to address specific challenges concerning LC screening and GC mortality [12,13]. To facilitate real-world applications, different ethnicand culture-based populations should be sampled. Here, we carried out a VOC-based clinical trial for GC and LC detection in China to classify these two major malignancies with different genetic and cultural backgrounds, using our developed sensors [1] with newly-developed sensor-printing and sampling methods.

【 授权许可】

CC BY|CC BY-NC-ND