The genetic influence of the brain-derived neurotrophic factor Val66Met polymorphism in chronic low back pain

Advances in Rheumatology

article

Yamada, Angela Shiratsu¹  Antunes, Flavia Tasmim Techera¹  Ferraz, Camila²  de Souza, Alessandra Hubner³  Simon, Daniel¹ 

[1] Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA);Human Molecular Genetics Laboratory, Lutheran University of Brazil (ULBRA);Biochemical and Molecular Pharmacology from the Federal University of Minas Gerais

关键词: Central sensitization;    Catastrophizing;    BDNF;    Polymorphism;    Single nucleotide polymorphism;    Val66Met;   

DOI  :  10.1186/s42358-021-00183-7

学科分类：地球科学(综合)

来源: Springer

【 摘 要 】

The Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF) gene is a potential biomarker of vulnerability to pain. Thus, the present study aimed to investigate the association of this polymorphism with clinical and biopsychosocial factors in patients with chronic low back pain (CLBP). A total of 107 individuals with CLBP answered questionnaires that were validated and adapted for the Brazilian population, including the Brief Inventory of Pain, the Central Sensitization Inventory, the Roland Morris Disability Questionnaire, the Tampa Scale for Kinesiophobia, the Pain Catastrophizing Scale, the Survey of Pain Attitude-Brief, and the Hospital Anxiety and Depression Scale. All of the subjects were genotyped for the BDNF Val66Met polymorphism. The sample showed moderate scores of disability, central sensitization, and kinesiophobia, in addition to mild anxiety, hopelessness, and ruminant thoughts. No significant association was observed between the Val66Met polymorphism and the variables analyzed. Besides, there was no relationship between the BDNF Val66Met polymorphism with CSI, catastrophization, or disabilities that were generated by CLBP. The results showed that the Val66Met polymorphism of the BDNF gene was not associated with clinical and biopsychosocial characteristics of CLBP in the sample studied.

【 授权许可】

CC BY