NaSH-HCl mediated reduction of sulfoxides into sulfides under organic solvent-free reaction conditions

Green Chemistry Letters and Reviews

article

Anže Zupanc¹  Marjan Jereb¹ 

[1] University of Ljubljana, Faculty of Chemistry and Chemical Technology

关键词: Sulfoxides;    reduction;    sulfides;    solvent-free;   

DOI  :  10.1080/17518253.2020.1838625

学科分类：化学（综合）

来源: Taylor & Francis

【 摘 要 】

NaSH·H 2 O and 37% aqueous solution of HCl were employed in reduction of sulfoxides to sulfides at room or elevated temperature in the absence of organic reducing agent and solvent-free reaction conditions. Operationally simple transformation took place in the presence of air and in the absence of heavy metals and organic reagents, yielding sodium chloride and sulfur as non-hazardous waste. Heterogeneous reaction conditions proved challenging, particularly in the cases of more hydrophobic substrates, requiring elevated amount of reactants and temperature. Products were isolated by extraction with tert -butyl methyl ether and “filtered” over a short pad of silica gel. Scale-up reaction was demonstrated, including completely solvent-free isolation and purification of the product. A potential reaction course was proposed.

【 授权许可】

CC BY|CC BY-NC