Therapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic Inflammation

Online journal of biological sciences

article

Ahmed F. Hasan¹  Thulfiqar F. Mutar²  Ehab Moustafa Tousson³  Shatha Ghazi Felemban⁴ 

[1] Department of Biology, Al-Farabi University College;Department of Medical Laboratory Techniques, Al-Maarif University College;Department of Zoology, Faculty of Science, Tanta University;Medical Laboratory Science, Fakeeh College for Medical Science

关键词: Amitriptyline;    Turnera diffusa (Damiana);    Liver Toxicity;    Proliferation;    Apoptosis;   

DOI  :  10.3844/ojbsci.2021.395.408

学科分类：生物科学（综合）

来源: Science Publications

【 摘 要 】

Tricyclic Antidepressants Including Amitriptyline (AMI), stop the reabsorption of norepinephrine and serotonin, so the levels of transmitters is elevated in the brain to lead to several side effects. Therefore, current study aimed to assay liver dysfunction that attended by AMI administration and monitoring of damiana Turnera diffuse role as adjuvant therapy to improving amitriptyline hepatic effects in male rats. 60 rats (adult, male, albino) were used divided into six groups (n = 10); 1st group, control; 2nd group, damiana; 3rd group, AMI; 4th group, co-treated AMI with damiana; 5th group, post-treated AMI with damiana and 6th group, self-healing AMI. Results showed that; AMI induces an elevation in AST, ALT and ALP; while it reduced albumin and total protein content. Besides, autoimmune liver disorders (ANA), hepatic DNA damage, p53 and PCNA protein expressions and histopathological injury were detected. However, the groups administered with damiana showed positive effects by increasing cellular response and reducing pathological changes. It concluded that treatment with AMI causes liver dysfunction, while damiana can: Protective against the toxic effects induced by AMI in rats.

【 授权许可】

CC BY