The Antinociceptive Effects of Central and Peripheral Administration of Peganum harmala L. Extracts in Animal Models

Online journal of biological sciences

article

Rachida Aboufatima¹  Zahra Sokar²  Abderrahman Chait²  Loubna Farouk²  Mehdi Ait Laaradia²  Sara Oufquir²  Laadraoui Jawad²  Abderrazak El Alami²  Zineb El Gabbas²  Kenza Bezza²  Fatim Zahra Marhoume² 

[1] University Sultan Moulay Slimane;University Cadi Ayyad

关键词: Peganum harmala;    Antinociceptive Activity;    Writhing Test;    Tail Flick Test;    Hot Plate;   

DOI  :  10.3844/ojbsci.2021.267.279

学科分类：生物科学（综合）

来源: Science Publications

【 摘 要 】

The medicinal plant Peganum harmala has been used in traditional Moroccan medicine to accelerate the healing process of various diseases and to relieve the pain. The antinociceptive effect of the Aqueous (AE), Dichloromethane (DE) and Butanolic (BE) extracts of the Peganum harmala L. was tested in mice and rats by chemical and thermal models. Plant seed extracts were given intraperitoneally 30 min before the 0.6% acetic acid injection. Dichloromethane (DE) at doses of 25 mg/kg (68.4%; p0.05), 50 mg/kg (24.39%; p<0.05) and BE in doses 25 mg/kg (36.82%; p<0.001), 50 mg/kg (74.26%; p<0.001) induced decrease in torsional reaction relative to control group. The DE, BE and AE (25, 50 mg/kg, intraperitoneally injection (i.p.,); 60 µg/kg, intracerebroventricular injection (i.c.v.,)) extracts of P. harmala generated a significant latency increase in the tail-flick response to thermal stimulation and generated a significant increase in the reaction time in the hot plate test. Whereas in formalin test, DE, BE and AE revealed a significant impact on both phases when given by intraperitoneal route. The antinociceptive effect of extracts was lower than morphine (10 mg/kg, i.p.,) in the hot-plate test and in both the phases of formalin test. Data suggest that extracts of P. harmala have inhibitory activity on the mechanisms of peripheral and central pain. Analgesic activity of this plant could potentially be associated with the presence of alkaloids, flavonoids, tannins, saponins and steroids in all P. harmala (Linn) seed extracts. It seems that the reason of popular use to relieve some pains.

【 授权许可】

CC BY