Potential Pathomechanism of Neuro-COVID-19

Online journal of biological sciences

article

Abir Fguirouche¹  Nissrine Louhab¹  Mohamed Chraa¹  Najib Kissani¹  Brahim Admou² 

[1] Cadi Ayyad University;University Hospital Mohamed VI

关键词: Sars-CoV-2;    COVID-19;    Nervous System;    Pathomechanisms;    Cytokine Storm;   

DOI  :  10.3844/ojbsci.2020.232.238

学科分类：生物科学（综合）

来源: Science Publications

【 摘 要 】

Gathered data about SARS-CoV-2 have shown strong evidence in terms of neuroinvasive and neurotropic capacities of the virus to reach and cause eventual damage to the Central Nervous System. The spread of the virus may occur through direct and indirect ways, leading to anosmia and/or ageusia. These signs have been observed in many COVID-19 patients and are then included in the diagnostic criteria for Neuro-COVID-19. The invasion of SARS-CoV-2 into the dorsal vagal complex of the brainstem has a harmful impact on the respiratory rhythm, with even respiratory failure. There is evidence that immune response abnormalities including cytokine storm and neuro-inflammation influence not only the disease severity, but also the occurrence of neurological and neurodegenerative manifestations. Many umbrella zones remain unclear about Neuro-COVID-19, which requires more consideration in its clinical, biological and therapeutic aspects and may open new research perspectives.

【 授权许可】

CC BY