Transdermal delivery systems in cosmetics

Biomedical Dermatology

article

Kim, Byel¹  Cho, Hang-Eui¹  Moon, Sun He¹  Ahn, Hyun-Jung¹  Bae, Seunghee¹  Cho, Hyun-Dae³  An, Sungkwan¹ 

[1] Department of Cosmetics Engineering, Graduate School of Konkuk University;Incheon;Creative Innovation Research Center, Ltd;Yeosiya Beauty Academy;Amorepacific Corporation

关键词: Transdermal delivery system;    Chemical enhancers;    Formulations;    Cosmetics;   

DOI  :  10.1186/s41702-020-0058-7

学科分类：皮肤病学

来源: Springer

【 摘 要 】

Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains a limiting factor in the penetration and absorption of these actives. Enhancement via modification of the stratum corneum by hydration, acting of chemical enhancers on the structure of stratum corneum lipids, and partitioning and solubility effects are described. This review summarizes the advances in the development and mechanisms of action of chemical components that act as permeation enhancers, as well as the advances in appropriate vehicles, such as gels, emulsions, and vesicular delivery systems, that can be used for effective transdermal delivery.

【 授权许可】

CC BY