Drug-related problems and associated factors in Ethiopia: a systematic review and meta-analysis

Southern Med Review

article

Adem, Fuad¹  Abdela, Jemal²  Edessa, Dumessa¹  Hagos, Bisrat³  Nigussie, Abraham²  Mohammed, Mohammed A.⁴ 

[1] Department of Clinical Pharmacy, School of Pharmacy, College of Health and Medical Sciences, Haramaya University;Department of Pharmacology and Toxicology, School of Pharmacy, College of Health and Medical Sciences, Haramaya University;Department of Pharmaceutical Supply Chain Management, College of Health and Medical Sciences, Haramaya University;School of Pharmacy, University of Auckland

关键词: Drug-Related problems;    Systematic review and meta-analysis;    Ethiopia;   

DOI  :  10.1186/s40545-021-00312-z

学科分类：药理学

来源: BioMed Central

【 摘 要 】

Drug-related problems (DRPs) can occur at any stages of medication use processes, and a single drug could be associated with multiple DRPs. Once happened, it adversely affects health outcomes. In Ethiopia, evaluation of the magnitude and factors associated with DRPs had not been attempted at the national level. The literature search was conducted in the following databases; PubMed, Embase, Medline, and Google Scholar. The quality of the included studies was checked using Joanna Brigg’s Institute (JBI’s) checklist, and data were analyzed using Stata software (version 14.0). The pooled estimate of DRPs was computed by a Random effect model (DerSimonian–Laird method). Cochran’s Q test (I2) statistic)), and Begg’s correlation and Egger’s regression test were assessed for heterogeneity and publication bias, respectively. Overall, 32 studies with a total sample size of 7,129 were included in the review. The estimated pooled prevalence of DRPs was 70% [0.70 (95% CI 0.64—0.76; I2 = 97.6% p = 0.000)]. Polypharmacy (taking ≥ 5 drugs) [RR = 1.3], medical comorbidity [RR = 1.3], poor medication adherence [RR = 1.7], uncontrolled blood pressure [RR = 1.4], substance use [RR = 1.2], type 2 diabetes [RR = 1.8], significant drug interaction [RR = 1.33], and a negative medication belief [RR = 3.72] significantly influenced the occurrence of DRPs. The estimated national prevalence of DRPs in Ethiopia was high. Presence of medical comorbidity, using multiple drugs, significant drug interaction, poor medication adherence, uncontrolled blood pressure, type 2 diabetes, substance use and a negative belief about medication significantly influenced the occurrence of DRPs. Initiating and/or strengthening pharmaceutical care services at the health care facilities could lower the occurrence of DRPs. PROSPERO registration number CRD42020162329.

【 授权许可】

Unknown