Characteristic molecular signature of pericardial effusion identifies malignant cancer in pericardial disorder patients

Molecular & Cellular Toxicology

article

Kim, Sang Yean¹  Eun, Jung Woo¹  Kim, Hyung Seok¹  Yang, Hee Doo¹  Na, Min Jeong¹  Ahn, Young Min⁴  Jung, Hae Ok⁵  Nam, Suk Woo¹ 

[1] Department of Pathology, College of Medicine, The Catholic University of Korea;Functional RNomics Research Center, The Catholic University of Korea;Department of Biomedicine and Health Sciences, Graduate School of Medicine, The Catholic University of Korea;Department of Kidney System, College of Oriental Medicine, Kyung Hee University;Division of Cardiology, Department of Internal Medicine, College of Medicine, Seoul St. Mary’s Hospital

关键词: Pericardial fluid;    Differential gene expression;    Diagnostic markers;    CD24;    SDC1;    ST14;   

DOI  :  10.1007/s13273-020-00076-8

来源: Korean Society of Toxicogenomics and Toxicoproteomics

【 摘 要 】

Background Pericardial effusion (PE) can develop in patients with virtually any condition that affects the pericardium, including acute pericarditis and a variety of systemic disorders. Thus, definite differentiation of malignant pericardial effusion and rapid diagnosis are known to have therapeutic and prognostic importance. Objective The aim of this study was to identify novel molecular markers for the detection of cancer in patients with pericardial disorder. Results We performed one-way ANOVA analysis of whole transcriptome scans of 18 PEs from the patients with pericardial disorder including cancer. It resulted in 4385 outlier genes. Hierarchical clustering analysis showed two distinct clusters [cancer patient’s PEs (G1 + G2) vs. non-cancer PEs (G3)] within the dendrogram. To identify cancer-specific molecular signature, Welch’s t test of G1 and G3 was performed and 1639 gene elements were suggested as stringent classifiers between cancer PE and non-cancer PE. Gene set enrichment analysis of PE signature suggested that CD24, SDC1, and ST14 were strong molecular markers for identifying cancer patients among patients with pericardial disorder. Conclusion Our results suggest that etiology-specific molecular signatures can discriminate cancer patients within pericardial disorder patients. CD24, SDC1, and ST14 are strong molecular markers for such discrimination.

【 授权许可】

Unknown