CSNK2B contributes to colorectal cancer cell proliferation by activating the mTOR signaling

Journal of Cell Communication and Signaling

article

Yu, Shijun¹  Hu, Qingqing¹  Fan, Kailing¹  Yang, Chen²  Gao, Yong¹ 

[1] Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine;Center for Disease Control and Prevention;Fudan University Pudong Institute of Preventive Medicine

关键词: CSNK2B;    mTOR;    Cell proliferation;    Tumorigenesis;    Colorectal cancer;   

DOI  :  10.1007/s12079-021-00619-1

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

The function of Casein kinase 2 beta (CSNK2B) in human malignancies has drawn increasing attention in recent years. However, its role in colorectal cancer (CRC) remains unclear. In the present study, we aimed to explore the expression and biological functions of CSNK2B in CRC. Public gene expression microarray data from online database and immunohistochemistry analysis demonstrated that CSNK2B was highly expressed in CRC tissues than in normal tissues. In vitro and in vivo cellular functional experiments showed that increased CSNK2B expression promoted CRC cell viability and tumorigenesis of CRC. Further western blots and rescue experiments confirmed that CSNK2B promoted CRC cell proliferation mainly by activating the mTOR signaling pathway. These findings identified CSNK2B as a novel oncogene contributing to the development of CRC.

【 授权许可】

CC BY