Exosomes and autophagy: rekindling the vesicular waste hypothesis

Journal of Cell Communication and Signaling

article

Gudbergsson, Johann Mar¹  Johnsen, Kasper Bendix² 

[1] Department of Health Science and Technology, Laboratory of Immunology and Cancer Biology, Aalborg University;Department of Health Technology, Center for Nanomedicine and Theranostics, Technical University of Denmark

关键词: Exosomes;    Extracellular vesicles;    Autophagy;    Secretory autophagy;    EV;    Vesicles;   

DOI  :  10.1007/s12079-019-00524-8

学科分类：分子生物学，细胞生物学和基因

来源: Springer

【 摘 要 】

Exosomes were first described as waste carriers implicated in reticulocyte maturation but has during the past decade been associated with many other cellular functions. The biogenesis of exosomes has been extensively studied and several protein machineries have been identified to dictate their production and release. The newly discovered branches of the autophagy system implicate secretion of waste in endosomal-derived vesicles as is thought for exosome release. Many of the proteins that have been identified as responsible for the formation and release of these vesicles are the same as those identified in exosome biogenesis. In this Perspective, we discuss the possibility of exosomes being a part of the autophagy machinery and the consequences this could have on interpretation of exosome functions.

【 授权许可】

CC BY