Accuracy of One-Step Nucleic Acid Amplification in Detecting Lymph Node Metastases in Endometrial Cancer

Pathology oncology research: POR

article

Raffone, Antonio¹  Travaglino, Antonio²  Santoro, Angela³  Esposito, Italia¹  Angelico, Giuseppe³  Spadola, Saveria³  Zannoni, Gian Franco³ 

[1] Gynecology and Obstetrics Unit, Department of Neurosciences, Reproductive Sciences and Dentistry, School of Medicine, University of Naples Federico II;Anatomic Pathology Unit, Department of Advanced Biomedical Sciences, University of Naples Federico II;Pathology Unit, Department of Woman and Child Health, Agostino Gemelli University Polyclinic, Catholic University of the Sacred Heart

关键词: OSNA;    Sentinel lymph node;    Endometrial cancer;    Intraoperative;    Ultrastaging;    Tailored medicine;   

DOI  :  10.1007/s12253-019-00727-9

来源: Springer

【 摘 要 】

One-step nucleic acid amplification (OSNA) is used to intraoperatively detect sentinel lymph node metastases in breast cancer. OSNA has also been proposed in endometrial cancer, but evidence in this regard is unclear to define the diagnostic accuracy of OSNA in detecting lymph node metastases in endometrial cancer. A systematic review and meta-analysis was performed by searching 8 electronic databases from their inception to March 2019 for studies testing the diagnostic accuracy of OSNA in detecting sentinel lymph node metastasis in endometrial cancer. Pathologic ultrastaging was the reference standard. Sensitivity, specificity, positive and negative likelihood ratio (LR+ and LR-), diagnostic odds ratio (DOR) and area under the curve (AUC) on SROC curve were calculated. Four studies with 237 patients and 691 lymph nodes were included. OSNA showed sensitivity = 0.88, specificity = 0.93, LR + =17.95, LR- = 0.15, DOR = 191.23 and high diagnostic accuracy (AUC = 0.959). OSNA appears as a highly accurate tool for intraoperative assessment of sentinel lymph node in endometrial cancer.

【 授权许可】

Unknown