miR-370 Sensitizes TMZ Response Dependent of MGMT Status in Primary Central Nervous System Lymphoma

Pathology oncology research: POR

article

Li, Xinwei¹  Xu, Xueying¹  Chen, Keng²  Wu, Haijian¹  Wang, Yirong¹  Yang, Shuxu¹  Wang, Kun² 

[1] Department of Neurosurgery, Sir Run Run Shaw Hospital, Medical College, Zhejiang University;Department of Neurosurgery, Hangzhou Xiasha Hospital, Sir Run Run Shaw Hospital, Medical College, Zhejiang University

关键词: Primary central nervous system lymphoma;    miR-370;    MGMT;    Temozolomide;    Drug resistance;   

DOI  :  10.1007/s12253-019-00605-4

来源: Springer

【 摘 要 】

Primary central nervous system lymphoma (PCNSL) is an aggressive and rare subtype of non-Hodgkin lymphoma, arising exclusively in the CNS with a poor prognosis. Previous evidence has proved that MGMT was a promising target involving in TMZ resistance of PCNSL. Our study described a new miR-370-mediated mechanism of MGMT regulation in PCNSL. We first showed that miR-370 was downregulated in PCNSL tissues, while MGMT was inversely overexpressed. It was also observed that miR-370 suppressed the expression of MGMT. Additionally, upregulation of miR-370 significantly increased TMZ sensitivity dependent of MGMT, thus suppressed Raji cell proliferation and induced apoptosis in vitro. In conclusion, these results suggest that miR-370 is a potential target in PCNSL treatment.

【 授权许可】

Unknown