Assessment of Gastritis and Gastric Cancer Risk in the Chilean Population Using the OLGA System

Pathology oncology research: POR

article

Bellolio, Enrique¹  Riquelme, Ismael³  Riffo-Campos, Angela L.¹  Rueda, Carlos⁴  Ferreccio, Catterina⁵  Villaseca, Miguel¹  Brebi, Priscilla¹  Muñoz, Sergio⁸  Araya, Juan Carlos¹ 

[1] Department of Pathological Anatomy, School of Medicine, Universidad de La Frontera;Instituto de Patología Celular y Molecular;Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile;Gastroenterologist;School of Medicine, Pontificia Universidad Católica de Chile;Advanced Center for Chronic Diseases (ACCDiS);Laboratory of Molecular Pathology, Department of Pathological Anatomy, School of Medicine, Center of Excellence in Translational Medicine - Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera;Department of Public Health, School of Medicine, Universidad de La Frontera

关键词: The OLGA system;    Helicobacter pylori infection;    Gastric atrophy;    Metaplasia;    Gastric cancer;    Chilean population;   

DOI  :  10.1007/s12253-018-0532-3

来源: Springer

【 摘 要 】

Gastric cancer (GC) is the first cancer-related cause of death in Chile; however, no plan for GC early detection has been implemented in this country. The OLGA system characterizes gastritis from stages 0 to IV according to the risk of developing GC based on H. pylori infection, atrophy, metaplasia and GC. In this study, the performance of the OLGA system was evaluated in 485 Chilean patients receiving routine endoscopy to improve the detection of early GC or preneoplastic lesions. The results showed that OLGA scores, atrophy, metaplasia and GC increased significantly with age (p  2 between 45 and 56 years old, because this group showed atrophy and intestinal metaplasia more frequently. Therefore, biennial endoscopic surveillance of patients with an OLGA >2 can be an important health policy in Chile for diagnosing GC in its early stages and reducing mortality over the next two decades.

【 授权许可】

Unknown