LncRNA EGOT Promotes Tumorigenesis Via Hedgehog Pathway in Gastric Cancer

Pathology oncology research: POR

article

Peng, Wei¹  Wu, Jianzhong²  Fan, Hong³  Lu, Jianwei¹  Feng, Jifeng¹ 

[1] Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital;Laboratory of Cancer Research, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital;Department of Gastroenterology, First People′s Hospital of Yunnan Province

关键词: Gastric cancer;    EGOT;    lncRNA;    Tumorigenesis;    Hedgehog;   

DOI  :  10.1007/s12253-017-0367-3

来源: Springer

【 摘 要 】

Gastric cancer (GC) is one of the mostly terminal malignancies with poor prognosis. Long noncoding RNA EGOT (EGOT) acts as a crucial regulator in the breast cancer. However, the function of EGOT in GC remains unknown. This work was to explore the clinical value and biological significance of EGOT in GC. EGOT levels in GC tissue and cell were analyzed by qRT–PCR. After knockdown of EGOT, GC cell growth and cycle progression were detected. The expression of EGOT was observably elevated in GC. Upregulation of EGOT was related with lymphatic metastasis and TNM stage. In addition, knockdown of EGOT by siRNA could significantly inhibit GC cell proliferation and arrest cycle progression in G1 phase. Moreover, EGOT mediated cyclin D1 expression in GC cells which was regulated by Hedgehog pathway. Further, loss of EGOT downregulated Hedgehog signaling pathway in GC cells. EGOT functions as an oncogene in GC, and may be useful as a conceivable diagnostic and prognostic biomarker for GC tumorigenesis.

【 授权许可】

Unknown