Season Dependent Changes in the Expression of Protein Kinase C Isoenzymes in a Female Patient with Systemic Lupus Erythematosus

Pathology oncology research: POR

article

Sipka, Sándor¹  Brugós, Boglárka¹  Czifra, Gabriella²  Griger, Zoltán¹  Balogh, Norbert²  Tarr, Tünde¹  Papp, Gábor¹  Bíró, Tamás²  Zeher, Margit¹ 

[1] Division of Clinical Immunology, Faculty of Medicine, University of Debrecen;Department of Physiology, Faculty of Medicine, University of Debrecen

关键词: European white women;    Peripheral blood mononuclear cells (PBMC);    Protein kinase C (PKC);    Season dependence;    Systemic lupus erythematosus (SLE);   

DOI  :  10.1007/s12253-019-00591-7

来源: Springer

【 摘 要 】

We aimed to answer the question whether the decreased expression of protein kinase C (PKC) isoenzymes in the peripheral blood mononuclear cells (PBMC) of patients with systemic lupus erythematosus (SLE) is inherited or not. For this reason we examined the expression of PKC isoenzymes in a European white girl with acute SLE and in her healthy mother and father simultaneously in summer and winter during one year using western blotting and densitometry. We found that in the father the expression of PKC isoenzymes did not differ from that of eight healthy controls included women and men. However, in the “SLE-free” mother and in the patient arrived in July with acute symptoms of lupus, the expression of PKC isoenzymes showed a season dependent undulation in parallel. Namely, in summer the expression values were significantly lower, in winter they were significantly higher than those in the controls. Thus, the decreased expression of PKC isoenzymes in the PBMC of SLE patient is not a disease specific marker; it appears also in her lupus free mother. This phenomenon may be due to a season dependent female genetic background. However, the low PKC levels in summer can still decrease further the low production of IL-2 in T cells of lupus patients augmenting the existing AP-1 defects. This is the first report on the season and female dependent inherited changing of PKC expression in a European white patient with SLE and her mother. Further studies are needed to confirm these findings in other populations.

【 授权许可】

Unknown