A Comprehensive Meta-Analysis of Association between EGFR Mutation Status and Brain Metastases in NSCLC

Pathology oncology research: POR

article

Tan, Li¹  Ren, Juan²  Wu, Yinying³  Ma, Xiaowei¹  Yan, Yanli¹  Shao, Shuai¹  Liu, Jiaxin¹  Ma, Hailin²  Liu, Rui²  Chai, Linyan² 

[1] Medical school, Xi’an Jiaotong University;Department of Oncology Radiotherapy, First Affliated Hospital, Xi’an Jiaotong University;Department of Medical Oncology, First Affiliated Hospital of Xi’an Jiaotong University

关键词: Epidermal growth factor receptor;    NSCLC;    Brain metastases;    Meta-analysis;   

DOI  :  10.1007/s12253-019-00598-0

来源: Springer

【 摘 要 】

Non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutation have different clinicopathological characteristics compared with EGFR wild type NSCLC. A growing number of studies focused on the relevance between EGFR mutation status and brain metastases (BM) in NSCLC, but it remains controversial. Therefore, this study performed a comprehensive meta-analysis to untangle this issue. Several electronic databases including Pubmed, Embase, Web of science and Cochrane database were thoroughly searched. The odds ratio (OR) with 95% confidence interval (95%CI) was pooled to evaluate the relevance. Meta-regression analysis and subgroup analysis were conducted according to the heterogeneity. A total of 26 studies were identified finally in this meta-analysis. The overall OR was 1.58 (95%CI: 1.36–1.84), which indicated that EGFR mutation had a positive association with BM of NSCLC. The subgroup analysis resulted from eleven studies with lung adenocarcinoma revealed a higher possibility of BM in NSCLC with EGFR mutation compared with EGFR wild (p < 0.05). There was no significant difference in the risk of BM between NSCLC EGFR exon 19 mutation and exon 21 point mutation (p = 0.23). This meta-analysis suggests that EGFR mutation can be a risk factor for BM in NSCLC.

【 授权许可】

Unknown