Protein Expression Analysis in Uterine Cervical Cancer for Potential Targets in Treatment

Pathology oncology research: POR

article

Blancas, Sugela¹  Medina-Berlanga, Rogelio¹  Ortíz-García, Liliana³  Loredo-Ramírez, Alfredo⁴  Santos, Leticia¹ 

[1]Instituto Potosino de Investigación Científica y Tecnológica

[2]Universidad Autónoma de Aguascalientes

[3]Universidad Politécnica de Pénjamo

[4]Laboratorio de Patología Quirúrgica

关键词: Uterine cervical cancer;    SEL1L;    Notch3;    SOCS3;    Immunohistochemistry;    Tissue microarray;   

DOI  :  10.1007/s12253-018-0401-0

来源: Springer

【 摘 要 】

Specific markers in lesions of the human uterine cervix cancer (UCC) are still needed for prognostic, diagnostic and/or therapeutic purposes. In this study we evaluated key molecules at protein level between normal epithelium, cervical intraepithelial neoplasia (CIN1–3) and invasive cancer of a group of molecules previously reported at mRNA level. For that purpose, human formalin-fixed paraffin embedded tissue microarrays (TMAs) were constructed containing 205 Mexican tissue core specimens. Immunohistochemistry and quantitative analysis of histological staining was performed against twenty-two distinct proteins for each core and the processing platform ImageJ. In the progression of the disease we found key statistical differences for the proteins SEL1, Notch3 and SOCS3. High expressions of SEL1L, Notch3 and SOCS3 have potential value to increase the prognostic of UCC in combination with markers such as p16INK4a. This study identified key drivers in cervical carcinogenesis that should be evaluated for the development of UCC therapies.

【 授权许可】

Unknown