Analysis of an improved fractional-order model of boundary formation in the Drosophila large intestine dependent on Delta-Notch pathway

Advances in Difference Equations

article

Sun, Deshun¹  Lu, Lingyun³  Liu, Fei⁴  Duan, Li¹  Wang, Daping¹  Xiong, Jianyi¹ 

[1] Shenzhen Key Laboratory of Tissue Engineering, Shenzhen Laboratory of Digital Orthopedic Engineering, Shenzhen Second People’s Hospital, The First Hospital Affiliated to Shenzhen University, Health Science Center;Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences;Nanjing Research Institute of Electronic Engineering;School of Software Engineering, South China University of Technology

关键词: Delta-Notch signaling pathway;    Fractional-order differential equations;    Local stability analysis;    Sensitive analysis;   

DOI  :  10.1186/s13662-020-02836-1

学科分类：航空航天科学

来源: SpringerOpen

【 摘 要 】

In this paper, an improved fractional-order model of boundary formation in the Drosophila large intestine dependent on Delta-Notch pathway is proposed for the first time. The uniqueness, nonnegativity, and boundedness of solutions are studied. In a two cells model, there are two equilibriums (no-expression of Delta and normal expression of Delta). Local asymptotic stability is proved for both cases. Stability analysis shows that the orders of the fractional-order differential equation model can significantly affect the equilibriums in the two cells model. Numerical simulations are presented to illustrate the conclusions. Next, the sensitivity of model parameters is calculated, and the calculation results show that different parameters have different sensitivities. The most and least sensitive parameters in the two cells model and the 60 cells model are verified by numerical simulations. What is more, we compare the fractional-order model with the integer-order model by simulations, and the results show that the orders can significantly affect the dynamic and the phenotypes.

【 授权许可】

CC BY