Distinct Antiviral Properties of Two Different Bacterial Lysates

Canadian Respiratory Journal

article

Michael Roth¹  Hanif J. Khameneh²  Lei Fang¹  Michael Tamm¹  Giovanni A. Rossi³ 

[1]Pulmonary Cell Research, DBM University Basel and Pneumology Clinic, University Hospital Basel

[2]Institute for Research in Biomedicine, Faculty of Biomedical Sciences, Università Della Svizzera Italiana

[3]Department of Pediatrics, Pulmonology and Allergy Units, IRCCS Istituto Giannina Gaslini

DOI  :  10.1155/2021/8826645

学科分类：工程和技术（综合）

来源: Hindawi Publishing Corporation

【 摘 要 】

Oral bacterial lysates (OBLs) can reduce the frequency and severity of recurrent respiratory tract infections in children from viral and bacterial origins. OBL-induced early innate immune reaction was already shown, but the specific features of different OBLs have never been studied and compared. A study was conducted to assess in vitro the protective effects on rhinovirus- (RV-) infected human bronchial epithelial cells (BECs) of two slightly different OBLs: OM-85 and Pulmonarom. Furthermore, since immune cells represent the key arm for antiviral defence, the capacity of these OBLs to induce selected cytokine production in mouse bone marrow-derived DCs (BMDCs) was also evaluated. Although different OBLs may share some mechanisms to protect host cells from virus infection, some product-specific antimicrobial activities were observed on RV-infected human BECs and mouse BMDCs. These results are consistent with a product-specific response possibly triggered by different pathogen-associated molecular patterns (PAMPs) contained in OBLs.

【 授权许可】

CC BY