Immune Cell Landscape in Gastric Cancer

Journal of biomedicine & biotechnology

article

Yang Yang¹  Wei He¹  Zi-rui Wang¹  Yu-jiao Wang¹  Lan-lan Li¹  Jian-zhong Lu¹  Yan Tao¹  Jing Zhang¹  Sheng-jun Fu¹  Zhi-ping Wang¹  Shan-hui Liu¹ 

[1] The Second Hospital of Lanzhou University, Lanzhou University;The Second Clinical Medical College of Lanzhou University, Lanzhou University;Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University;Institute of Urology, Lanzhou University Second Hospital;Key Laboratory of Urological Disease of Gansu Province;Institute of Gansu Nephro-Urological Clinical Central

DOI  :  10.1155/2021/1930706

来源: Hindawi Publishing Corporation

【 摘 要 】

Background . The tumor-infiltrating immune cells are closely associated with the prognosis of gastric cancer (GC). This article is aimed at determining the composition change of immune cells and immune regulatory factors in GC and normal tissues, depicting their prognosis value in GC, and revealing the relationship between them and GC clinical parameters. Methods . We used CIBERSORT to calculate the proportion of 22 immune cells in the GC or normal tissues; a - test was applied to assess the expression difference of immune cells and immune regulatory factors in normal and GC tissues. The relationship of the immune cells, immune regulatory factors, and GC patients’ clinical characteristics was assessed by univariate analysis. Results . In this study, we found that the proportion of macrophages increased, while plasma cells and monocytes decreased in GC tissues. In these immune fractions, Tregs and naïve B cells were found to be correlated with GC patients’ prognosis. Interestingly, the expression of immune regulatory factors was ambiguous with their classical function in GC tissues. For example, TIM-3, FOXP3, and CMTM6 were overexpressed, while CD27 and PD-1 were underexpressed in GC tissues. We also found that IDO1, PD-1, TIGIT, and TIM-3 were highly expressed in high-grade GC tissues, the HERC2 expression level was related to patients’ gender, and the TIGIT expression level was sensitive to targeted therapy. Furthermore, our results suggested that the infiltration of Tregs and naive B cells was strongly correlated with the T stage, radiation therapy, targeted molecular therapy, and the expression levels of TIM-3 and FOXP3 in GC. Conclusion . The expression pattern of tumor-infiltrating immune cells and immune regulatory factors was systematically depicted in the GC tumor microenvironment, indicating that individualized treatment based on the tumor-infiltrating immune cells and immune regulatory factors may be beneficial to GC patients.

【 授权许可】

Unknown