Diaphragm thickening fraction predicts noninvasive ventilation outcome: a preliminary physiological study

Critical Care

Rossana Moroni¹  Giuseppe Bello²  Sonia D’Arrigo²  Davide Eleuteri²  Domenico Luca Grieco²  Maria Grazia Bocci²  Giovanna Mercurio²  Maria Giuseppina Annetta²  Luca Salvatore Menga²  Massimo Antonelli³  Mariano Alberto Pennisi³  Giorgio Conti³  Luca Montini³  Anna Romano⁴ 

[1] Biostatistics, Office of the Scientific Director, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy;Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy;Department of Anesthesiology, Intensive Care and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli, 8, 00168, Rome, Italy;Institute of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart, Rome, Italy;Institute of Anesthesiology and Intensive Care Medicine, Catholic University of the Sacred Heart, Rome, Italy;

关键词: Acute respiratory failure;    Noninvasive ventilation;    Ultrasound;    Diaphragm thickening fraction;    Rapid shallow breathing index;   

DOI  :  10.1186/s13054-021-03638-x

来源: Springer

【 摘 要 】

BackgroundA correlation between unsuccessful noninvasive ventilation (NIV) and poor outcome has been suggested in de-novo Acute Respiratory Failure (ARF) patients. Consequently, it is of paramount importance to identify accurate predictors of NIV outcome. The aim of our preliminary study is to evaluate the Diaphragmatic Thickening Fraction (DTF) and the respiratory rate/DTF ratio as predictors of NIV outcome in de-novo ARF patients.MethodsOver 36 months, we studied patients admitted to the emergency department with a diagnosis of de-novo ARF and requiring NIV treatment. DTF and respiratory rate/DTF ratio were measured by 2 trained operators at baseline, at 1, 4, 12, 24, 48, 72 and 96 h of NIV treatment and/or until NIV discontinuation or intubation. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the ability of DTF and respiratory rate/DTF ratio to distinguish between patients who were successfully weaned and those who failed.ResultsEighteen patients were included. We found overall good repeatability of DTF assessment, with Intra-class Correlation Coefficient (ICC) of 0.82 (95% confidence interval 0.72–0.88). The cut-off values of DTF for prediction of NIV failure were < 36.3% and < 37.1% for the operator 1 and 2 (p < 0.0001), respectively. The cut-off value of respiratory rate/DTF ratio for prediction of NIV failure was > 0.6 for both operators (p < 0.0001).ConclusionDTF and respiratory rate/DTF ratio may both represent valid, feasible and noninvasive tools to predict NIV outcome in patients with de-novo ARF.Trial registration ClinicalTrials.gov Identifier: NCT02976233, registered 26 November 2016.

【 授权许可】

CC BY