期刊论文详细信息
Thrombosis Journal
Coagulation abnormalities in childhood acute lymphoblastic leukemia: assessing the impact of L-asparaginase therapy in Ghana
David Ofosu Ntiamoah1  Ganiwu Abdul2  Alexander Yaw Debrah2  Gordon Asare Akuffo2  Benedict Sackey2  Otchere Addai-Mensah2  William Osei-OWusu2  Michael Owusu2  Lilian Antwi-Boateng2  Selina Mintaah2  Max Annani-Akollor3  Eddie-Williams Owiredu3 
[1] Department of Basic and Applied Biology, University of Energy and Natural Resources, Sunyani, Ghana;Department of Medical Diagnostics, Faculty of Allied Health Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;Department of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana;
关键词: Acute lymphoblastic leukemia;    Hypercoagulability;    Thrombosis;    Thromboembolic complications;   
DOI  :  10.1186/s12959-021-00297-4
来源: Springer
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【 摘 要 】

BackgroundAlthough the rate of childhood acute lymphoblastic leukemia (ALL) is increasing in Africa, there is a dearth of information on the disease and the dynamics of hemostatic parameters with therapy.MethodsIn this case-control study, we evaluated variations in the level/activity of selected coagulation parameters among cALL in Ghana and healthy controls stratified by stage of therapeutic management.ResultsIn all, the research recruited 104 participants comprising 26 cALL cases and 78 healthy controls. The cALL group had significantly higher prothrombin time (PT) (p = 0.001), activated partial thromboplastin time (APTT) (p < 0.0001) and D-dimers (p = 0.001) but lower platelet (PLT) count, protein C (PC) (p < 0.0001), protein S (PS) (p < 0.0001) and antithrombin III (ATIII) (p < 0.0001) compared to controls. Compared to the healthy controls, activity of PC was lower during induction (p < 0.0001), consolidation (p = 0.005) and maintenance phases of chemotherapy (p = 0.012) while activities of PS and ATIII were lower at both induction (p < 0.0001, p = 0.006) and consolidation (p < 0.0001, p = 0.018) phases of chemotherapy.ConclusionOur findings provide evidence in the context of Africa and corroborates previous reports that cALL could result in a state of hypercoagulability, possibly leading to a high risk of thrombosis and thromboembolic complications. This possibly increased risk is not limited to the induction phase but also the consolidation phase.

【 授权许可】

CC BY   

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