The association between family impact and health-related quality of life of children with idiopathic central precocious puberty in Chongqing, China

Health and Quality of Life Outcomes

Xiaohua Liang¹  Qin Lin²  Li Zeng³  Di Wu³  Shunqing Luo³  Ting Cheng³  Fang Tang³  Hong Yang³ 

[1] Clinical Epidemiology and Biostatistics Department, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation Center of Child Development and Critical Disorders, Children’s Hospital of Chongqing Medical University, Zhongshan 2nd Road No. 136, Yuzhong, 400016, Chongqing, China;Department of Endocrinology and Internal Medicine, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Zhongshan 2nd Road No. 136, Yuzhong, 400016, Chongqing, China;Department of General Medicine, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Children’s Hospital of Chongqing Medical University, Jinyu Avenue No. 20, Yubei, 400010, Chongqing, China;

关键词: Precocious puberty;    Child;    Quality of life;    Family impact;   

DOI  :  10.1186/s12955-021-01805-w

来源: Springer

【 摘 要 】

BackgroundIdiopathic central precocious puberty (ICPP) reduces patient health-related quality of life (HRQoL). The impacts of disease and treatment on families are also an important concern. This study aimed to assess the association between family impact and HRQoL of children with ICPP.MethodsWe conducted a case–control study in Chongqing, China. A case group of 134 children with ICPP aged 5–12 years and their caregivers was recruited from a children’s hospital in Chongqing. A total of 210 gender- and age-matched subjects from two primary schools were selected as controls. PedsQLTM4.0 Generic Core Scales (GCS) and PedsQL™ Family Impact Module (FIM) were used in this study.ResultsChildren with ICPP scored lower than controls in all HRQoL domains except physical functioning. In particular, the two groups were significantly different in emotional functioning scores (d = 0.414, P < 0.001). Compared with controls, ICPP families had lower scores in all dimensions of the FIM scale (d = 0.288–1.030, all P < 0.05). Factors associated with HRQoL of ICPP patients included: age of patients, type of medical treatment, employment status of caregivers, educational level of caregivers, parent HRQoL and family functioning (all P < 0.05).ConclusionsChildren with ICPP demonstrated lower quality of life and greater family impact compared to healthy controls. In addition, less impact of disease on parent HRQoL and family functioning was associated with better HRQoL of ICPP patients, patients aged older, treated with drug combination, cared by employed or well-educated caregivers reported better HRQoL. Health care professionals should pay more attention to younger patients treated with GnRHa alone, and provide targeted interventions for caregivers depending on their demographic background to reduce family impact and thereby improve patient HRQoL.

【 授权许可】

CC BY