Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients

eLife

Yongzhi Huang¹  Dianyou Li²  Shikun Zhan²  Bomin Sun²  Chunyan Cao²  Chencheng Zhang²  Yijie Lai²  Peng Huang²  Tao Wang²  Chao Zhang²  Jean Debarros³  Peter Brown³  Huiling Tan³ 

[1] Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China;Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom;Department of Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Medical Research Council (MRC) Brain Network Dynamics Unit at the University of Oxford, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom;

关键词: habenula;    prefrontal cortex-habenula network;    emotional stimuli;    theta / alpha oscillations;    deep brain stimulation;    depression;    Human;   

DOI  :  10.7554/eLife.65444

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is still poorly understood. We recorded local field potentials from bilateral habenula areas with simultaneous cortical magnetoencephalography in nine patients with psychiatric disorders during an emotional picture-viewing task. Transient activity in the theta/alpha band (5–10 Hz) within the habenula and prefrontal cortical regions, as well as the coupling between these structures, is increased during the perception and processing of negative emotional stimuli compared to positive emotional stimuli. The increase in theta/alpha band synchronization in the frontal cortex-habenula network correlated with the emotional valence but not the arousal score of the stimuli. These results provide direct evidence for increased theta/alpha synchrony within the habenula area and prefrontal cortex-habenula network in the perception of negative emotion in human participants.

【 授权许可】

CC BY