Effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in southern China

Journal of Orthopaedic Surgery and Research

Qiumei Liu¹  Quanhui Chen¹  Chunbao Mo¹  Junling Zhang¹  Jian Qin¹  Chuntao Nong¹  Jiansheng Cai¹  Shuzhen Liu¹  Xia Xu¹  Min Xu¹  Xu Tang¹  Huaxiang Lu²  Haoyu He³  Zhiyong Zhang⁴ 

[1] School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, China;School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, China;Department of Guangxi Science and Technology Major Project, Guangxi Zhuang Autonomous Region Center for Diseases Control and Prevention, 18 Jinzhou Road, Nanning, Guangxi Zhuang Autonomous Region, China;School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, China;Department of Quality Management, The Affiliated Hospital of Stomatology, Guangxi Medical University, 10 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, China;School of Public Health, Guangxi Medical University, 22 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, China;School of Public Health, Guilin Medical University, 20 Lequn Road, Guilin, Guangxi Zhuang Autonomous Region, China;

关键词: Hand grip strength;    Apolipoprotein E;    Single nucleotide polymorphism;    Gene-environment interaction;   

DOI  :  10.1186/s13018-021-02522-2

来源: Springer

【 摘 要 】

BackgroundHand grip strength is a complex phenotype. The current study aimed to identify the effects of the association between APOE rs405509 polymorphisms and gene-environment interactions on hand grip strength among middle-aged and elderly people in a rural population in Gongcheng, southern China.MethodsAPOE rs405509 polymorphisms in 1724 participants (695 men and 1029 women, aged 45–97 years old) were genotyped using the Sequenom MassARRAY platform. Statistical analysis was conducted using SPSS 21.0 and Plink 1.90.ResultsThe APOE rs405509 G allele was associated with lower hand grip strength in all participants (β = −1.04, P value <0.001), and the correlation seemed to be even stronger among women. A significant gene-environment interaction was observed between APOE rs405509 and smoking, especially in men. The hand grip strength of male smokers carrying the GG genotype was significantly higher than that of nonsmokers (P value = 0.004).ConclusionsAPOE rs405509 polymorphisms might be genetic factors that affect hand grip strength in a rural population in Gongcheng, southern China. The APOE rs405509-smoking interaction has an impact on hand grip strength.

【 授权许可】

CC BY