Prevalence of latent tuberculosis in patients with hematological neoplasms in a cancer referral hospital in Mexico City

BMC Infectious Diseases

Alexandra Martin-Onraet¹  Diana Vilar-Compte¹  Jaquelyn García-Tirado²  Erick Antonio Osorio-López³ 

[1] Department of Infectious Diseases, National Cancer Institute (Instituto Nacional de Cancerologia), Av. San Fernando 22, col. Sección XVI. 14000, Tlalpan Delegation, Mexico City, Mexico;Faculty of Medicine, National Autonomous University of Mexico (Universidad Nacional Autonoma de México), Mexico City, Mexico;Faculty of Medicine, National Autonomous University of Mexico (Universidad Nacional Autonoma de México), Mexico City, Mexico;Department of Infectious Diseases, National Cancer Institute (Instituto Nacional de Cancerologia), Av. San Fernando 22, col. Sección XVI. 14000, Tlalpan Delegation, Mexico City, Mexico;

关键词: Latent tuberculosis;    Hematologic malignancies;    Tuberculin skin test;   

DOI  :  10.1186/s12879-021-06236-y

来源: Springer

【 摘 要 】

ObjectiveTo determine the prevalence of Latent Tuberculosis in patients with hematological neoplasms at the Instituto Nacional de Cancerología in Mexico City using the Tuberculin skin test (TST).MethodsThis retrospective study included all patients with a recent diagnosis of hematological neoplasms who were admitted for treatment from 2017 to 2018 and who were screened for latent tuberculosis with the TST. The prevalence of latent tuberculosis in this group, tolerance and therapeutic adherence in treated patients are described.ResultsThe files of 446 patients with hematological malignancy who had a TST were reviewed. The prevalence of latent tuberculosis was 31.2% (n = 139). Ninety-three patients received isoniazid, 15.1% had some adverse reactions, but only 4 (4.3%) had to discontinue treatment. Two patients with latent tuberculosis under treatment with Isoniazid reactivated tuberculosis infection.ConclusionsThe prevalence in our study was within the range of other similar Mexican populations. Isoniazid treatment had an adequate tolerance and adherence. Longer follow-up could offer more information on the risk of reactivation in both groups.

【 授权许可】

CC BY