Inter-rater reliability of subthreshold psychotic symptoms in individuals with 22q11.2 deletion syndrome

Journal of Neurodevelopmental Disorders

Donna M. McDonald-McGinn¹  Leila Kushan¹  Wendy R. Kates²  Tyler M. Moore³  Robert Sean Gallagher³  Monica E. Calkins³  Raquel E. Gur⁴  Carrie E. Bearden⁵  Ronnie Weinberger⁶  Deby Salzer⁶  Dafna Sofrin Frumer⁶  Doron Gothelf⁷ 

[1] 22q and You Center, CHOP, Philadelphia, USA;Department of Psychiatry and Behavioral Sciences, State University of New York at Upstate Medical University, Syracuse, NY, USA;Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;Lifespan Brain Institute of Penn Medicine and the Children’s Hospital of Philadelphia (CHOP), Philadelphia, USA;Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA;Lifespan Brain Institute of Penn Medicine and the Children’s Hospital of Philadelphia (CHOP), Philadelphia, USA;Department of Child and Adolescent Psychiatry and Behavioral Sciences, CHOP, Philadelphia, USA;Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA;The Behavioral Neurogenetics Center, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Israel;The Behavioral Neurogenetics Center, Edmond and Lily Safra Children’s Hospital, Sheba Medical Center, Tel Hashomer, Israel;Sackler Faculty of Medicine and the Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel;

关键词: Velocardiofacial syndrome;    DiGeorge;    Subthreshold psychotic symptoms;    Structured Interview for Prodromal Syndromes (SIPS);    Scale of Prodromal Symptoms (SOPS);    Inter-rater reliability;    Psychosis risk syndrome;   

DOI  :  10.1186/s11689-021-09372-3

来源: Springer

【 摘 要 】

BackgroundPathways leading to psychosis in 22q11.2 deletion syndrome (22q11.2DS) have been the focus of intensive research during the last two decades. One of the common clinical risk factors for the evolution of psychosis in 22q11.2DS is the presence of positive and negative subthreshold psychotic symptoms. The gold standard for measuring subthreshold symptoms is the Structured Interview for Prodromal Syndromes (SIPS) and its accompanying Scale of Prodromal Symptoms (SOPS) ratings. Although the scale has been used by many centers studying 22q11.2DS, the inter-site reliability of the scale in this population has never been established.MethodsIn the present study, experienced clinical assessors from three large international centers studying 22q11.2DS independently rated video recordings of 18 adolescents and young adults with 22q11.2DS.ResultsThe intraclass correlations coefficients (ICCs) among three raters for the SOPS total scores, as well as for the positive, negative, and disorganization subscale scores, were good-to-excellent (ICCs range 0.73–0.93). The raters were also able to reliably determine the subjects’ subthreshold syndrome status (ICC = 0.71). The reliability of individual items was good-to-excellent for all items, ranging from 0.61 for motor disturbances [G3] to 0.95 for bizarre thinking.ConclusionsOur results show that trained clinicians can reliably screen for subthreshold psychotic symptoms in individuals with 22q11.2DS. To increase assessment reliability, we suggest specific clarifications and simplifications to the standard SIPS interview for future studies.

【 授权许可】

CC BY