Amelioration of hemodialysis-induced oxidative stress and fatigue with a hemodialysis system employing electrolyzed water containing molecular hydrogen

Renal Replacement Therapy

Yuki Kawai¹  Tamio Iwamoto¹  Nobuteru Kobayashi²  Mariko Yoshida²  Kazuhiko Shibata³  Naoaki Koguchi⁴  Hidehisa Satta⁴  Masaaki Nakayama⁵ 

[1] Department of Nephrology and Hypertension, Saiseikai Yokohama-shi Nanbu Hospital, Yokohama, Japan;Department of Nephrology, Yokohama City Minato Red Cross Hospital, Yokohama, Japan;Houshinkai Toshin Clinic, Yokohama, Japan;Houshinkai Yokodai Central Clinic, Yokohama, Japan;Kidney Center, St Luke’s International Hospital, 9-1 Akashicho, Chuo-ku, 1048560, Tokyo, Japan;Research Division of Dialysis Chronic Kidney Disease, Tohoku University Hospital, Sendai, Japan;

关键词: Hemodialysis;    Biocompatibility;    Oxidative stress;    Molecular hydrogen;    Dialysis-fatigue;   

DOI  :  10.1186/s41100-021-00353-9

来源: Springer

【 摘 要 】

BackgroundA novel hemodialysis (HD) system employing electrolyzed water containing molecular hydrogen (E-HD) has been developed to improve the bio-compatibility of HD. This study examined the impact of E-HD on changes in redox state during HD and HD-related fatigue.MethodThis single-arm, prospective observational study examined 63 patients on chronic HD (41 males; mean age, 72 ± 9 years; median duration of HD, 7 years). Redox parameters (serum myeloperoxidase [MPO], malondialdehyde-protein adduct [MDA-a], thioredoxin 1 [TRX]) during HD were compared between control HD (C-HD) and E-HD after 8 weeks. Fatigue was evaluated using a numerical rating scale (NRS) during the 8-week course.ResultsIn C-HD, an increase in serum MPO accompanied increases in both oxidative products (MDA-a) and anti-oxidant molecules (TRX). In E-HD, although increases in MPO were accentuated during HD, changes in MDA-a and TRX were ameliorated as compared with C-HD. In patients who showed HD-related fatigue (47%) during C-HD, change in MDA-a by HD was a risk factor for the presence of fatigue. During the 8 weeks of observation on E-HD, those patients displayed significant decreases in fatigue scores.ConclusionE-HD ameliorates oxidative stress and supports anti-oxidation during HD, suggesting improved bio-compatibility of the HD system. E-HD may benefit patients with HD-related fatigue, but the mechanisms underlying changes to oxidative stress have yet to be clarified.

【 授权许可】

CC BY