Low MSP-1 haplotype diversity in the West Palearctic population of the avian malaria parasite Plasmodium relictum

Malaria Journal

Vanessa A. Mata¹  Ricardo J. Lopes¹  Olof Hellgren²  Victor Kelbskopf²  Vincenzo A. Ellis³  Arif Ciloglu⁴  Xi Huang⁵  Mélanie Duc⁶  Abdullah Inci⁷  Sergei V. Drovetski⁸  Sargis A. Aghayan⁹ 

[1] CIBIO, Centro de Investigação Em Biodiversidade E Recursos Genéticos, InBIO Laboratório Associado, Universidade Do Porto, Vairão, Portugal;Department of Biology, Lund University, Lund, Sweden;Department of Biology, Lund University, Lund, Sweden;Department of Entomology and Wildlife Ecology, University of Delaware, Newark, DE, USA;Department of Biology, Lund University, Lund, Sweden;Department of Parasitology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey;Vectors and Vector-Borne Diseases Implementation and Research Center, Erciyes University, Kayseri, Turkey;Department of Biology, Lund University, Lund, Sweden;MOE Key Laboratory for Biodiversity Sciences and Ecological Engineering, Beijing Normal University, Beijing, China;Department of Biology, Lund University, Lund, Sweden;Nature Research Centre, Akademijos 2, 08412, Vilnius, Lithuania;Department of Parasitology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey;Vectors and Vector-Borne Diseases Implementation and Research Center, Erciyes University, Kayseri, Turkey;US Geological Survey, Eastern Ecological Research Center at Patuxent Research Refuge, 20705, Beltsville, MD, USA;Yerevan State University, 1 Alex Manoogian, 0025, Yerevan, Republic of Armenia;

关键词: Avian malaria;    Haemosporida;    Host specificity;    Merozoite surface protein 1;    Parasite population structure;    Plasmodium relictum;   

DOI  :  10.1186/s12936-021-03799-8

来源: Springer

【 摘 要 】

BackgroundAlthough avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested.MethodsThe genetic diversity of Plasmodium relictum was investigated by sequencing a portion (block 14) of the fast-evolving merozoite surface protein 1 (MSP1) gene in 75 different P. relictum infections from 36 host species. Furthermore, the full-length MSP1 sequences representing the common block 14 allele was sequenced in order to investigate if additional variation could be found outside block 14.ResultsThe majority (72 of 75) of the sequenced infections shared the same MSP1 allele. This common allele has previously been found to be the dominant allele transmitted in Europe.ConclusionThe results corroborate earlier findings derived from a limited dataset that the globally transmitted malaria parasite P. relictum exhibits very low genetic diversity in its Western Palearctic transmission area. This is likely the result of a recent introduction event or a selective sweep.

【 授权许可】

CC BY