Evaluation of a CTA-based convolutional neural network for infarct volume prediction in anterior cerebral circulation ischaemic stroke

European Radiology Experimental

Lasse Hokkinen¹  Marko Kangasniemi¹  Sauli Savolainen²  Teemu Mäkelä² 

[1] HUS Medical Imaging Centre, Radiology, University of Helsinki and Helsinki University Hospital, P.O. Box 340 (Haartmaninkatu 4), FI-00290, Helsinki, Finland;HUS Medical Imaging Centre, Radiology, University of Helsinki and Helsinki University Hospital, P.O. Box 340 (Haartmaninkatu 4), FI-00290, Helsinki, Finland;Department of Physics, University of Helsinki, P.O. Box 64, FI-00014, Helsinki, Finland;

关键词: Computed tomography angiography;    Stroke;    Deep learning;    Machine learning;    Convolutional neural network;   

DOI  :  10.1186/s41747-021-00225-1

来源: Springer

【 摘 要 】

BackgroundComputed tomography angiography (CTA) imaging is needed in current guideline-based stroke diagnosis, and infarct core size is one factor in guiding treatment decisions. We studied the efficacy of a convolutional neural network (CNN) in final infarct volume prediction from CTA and compared the results to a CT perfusion (CTP)-based commercially available software (RAPID, iSchemaView).MethodsWe retrospectively selected 83 consecutive stroke cases treated with thrombolytic therapy or receiving supportive care that presented to Helsinki University Hospital between January 2018 and July 2019. We compared CNN-derived ischaemic lesion volumes to final infarct volumes that were manually segmented from follow-up CT and to CTP-RAPID ischaemic core volumes.ResultsAn overall correlation of r = 0.83 was found between CNN outputs and final infarct volumes. The strongest correlation was found in a subgroup of patients that presented more than 9 h of symptom onset (r = 0.90). A good correlation was found between the CNN outputs and CTP-RAPID ischaemic core volumes (r = 0.89) and the CNN was able to classify patients for thrombolytic therapy or supportive care with a 1.00 sensitivity and 0.94 specificity.ConclusionsA CTA-based CNN software can provide good infarct core volume estimates as observed in follow-up imaging studies. CNN-derived infarct volumes had a good correlation to CTP-RAPID ischaemic core volumes.

【 授权许可】

CC BY