Temporal phylogeny and molecular characterization of echovirus 30 associated with aseptic meningitis outbreaks in China

Virology Journal

Wenrui Wang¹  Xiaoling Tian¹  Yulong He²  Hongying Li³  Zhenzhi Han⁴  Qiang Sun⁴  Wenbo Xu⁴  Yong Zhang⁴ 

[1] Inner Mongolia Center for Disease Control and Prevention, 010031, Huhhot, People’s Republic of China;Tongliao City Center for Disease Control and Prevention, 028000, Tongliao, People’s Republic of China;Tongliao City Hospital, 028000, Tongliao, People’s Republic of China;WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory of biosafety, National Health Commission Key Laboratory of Medical Virology, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, 102206, Beijing, People’s Republic of China;Center for Biosafety Mega-Science, Chinese Academy of Sciences, 430071, Wuhan, People’s Republic of China;

关键词: Echovirus 30 (E30);    Molecular epidemiology;    Phylodynamics;    Aseptic meningitis;   

DOI  :  10.1186/s12985-021-01590-4

来源: Springer

【 摘 要 】

BackgroundAn outbreak of aseptic meningitis occurred from June to August 2016, in Inner Mongolia Autonomous Region, China.MethodsTo determine its epidemiological characteristics, etiologic agent, and possible origin, specimens were collected for virus isolation and identification, followed by molecular epidemiological analysis.ResultsA total of 363 patients were clinically diagnosed from June 1st to August 31st 2016, and most cases (63.1%, n = 229) were identified between June 22nd and July 17th, with children aged 6 to 12 years constituting the highest percentage (68.9%, n = 250). All viral isolates from this study belonged to genotype C of echovirus 30 (E30), which dominated transmission in China. To date, two E30 transmission lineages have been identified in China, of which Lineage 2 was predominant. We observed fluctuant progress of E30 genetic diversity, with Lineage 2 contributing to increased genetic diversity after 2002, whereas Lineage 1 was significant for the genetic diversity of E30 before 2002.ConclusionsWe identified the epidemiological and etiological causes of an aseptic meningitis outbreak in Inner Mongolia in 2016, and found that Lineage 2 played an important role in recent outbreaks. Moreover, we found that Gansu province could play an important role in E30 spread and might be a possible origin site. Furthermore, Fujian, Shandong, Taiwan, and Zhejiang provinces also demonstrated significant involvement in E30 evolution and persistence over time in China.

【 授权许可】

CC BY