Serum pepsinogen levels in different regions of China and its influencing factors: a multicenter cross-sectional study

BMC Gastroenterology

Shizhu Liu¹  Hongguang Wang¹  Yinhu Luo²  Hongwei Xu³  Xueqiang He⁴  Dong Wang⁵  Hongbo Wu⁶  Hongzhi Xu⁷  Zhenya Song⁸  Yi Zhao⁸  Yuling Tong⁸  Hong Li⁹  Lirong Gong^1,10  Ping Shuai^1,10 

[1] Department of Gastroenterology, Jilin City People’s Hospital, Jilin, China;Department of Gastroenterology, Jingzhou Hospital of Traditional Chinese Medicine, Jingzhou, China;Department of Gastroenterology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, China;Department of Gastroenterology, No. 924 Hospital of the People’s Liberation Army of China, Guilin, China;Department of Gastroenterology, Shanghai Changhai Hospital, Shanghai, China;Department of Gastroenterology, The First Hospital Affiliated to AMU (Southwest Hospital), Chongqing, China;Department of Gastroenterology, Zhongshan Hospital Affiliated to Xiamen University, Xiamen, China;Department of General Practice/Health Management Center, The Second Affiliated Hospital of Zhejiang University, School of Medicine, No. 88 Jiefang Road, Hangzhou, China;Department of Health Medicine, Chinese PLA General Hospital, Beijing, China;Health Management Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China;

关键词: Serum pepsinogen;    Different regions of China;    Influencing factors;    Baseline survey;   

DOI  :  10.1186/s12876-021-01794-6

来源: Springer

【 摘 要 】

BackgroundThe aim of this study is to investigate the difference of serum pepsinogen (PG) baseline levels in different regions of China and its influencing factors.MethodsFrom October 2016 to October 2018, asymptomatic health checkup people who underwent nasal endoscopy in nine health management centers in different regions of China were collected. Lifestyle questionnaires were conducted, and serum PG and gastroscopy were performed. The differences in PG levels in baseline population (OLGA-0 grade) were studied according to geographical subregions of China. SPSS software was used for statistical analysis.Results1922 patients were included in the final analysis. Compared with the non-atrophy (OLGA-0) group, PGR levels in atrophy group (OLGA-I to IV) were significantly decreased with the atrophy degree (p < 0.05). A total of 1590 baseline people (OLGA-0) were included in the study, including 254 from South China, 574 from East China, 210 from Southwest China, 332 from Northeast China, and 220 from Central/Northern China. There were significant differences in baseline PGI levels among the five regions (p < 0.05). The PGII levels were also different among the five regions, except for Central/Northern versus Southern China. PGR (PGI/PGII ratio) levels in Southern China were higher than other four regions. Further studies were conducted on the related factors that might affect the baseline PG level, which was affected by nationality, dietary habits, smoking, Helicobacter pylori infection and other related factors.ConclusionInfluenced by many factors, the baseline PG levels are different in different regions of China. In the follow-up studies of PG cut-off value, different PG cut-off value based on region may be more effective in the screening of gastric cancer and precancerous lesions in China.

【 授权许可】

CC BY