Community-acquired fulminant Clostridioides (Clostridium) difficile infection by ribotype 027 isolate in Japan: a case report

Surgical Case Reports

Hayato Kimura¹  Shusaku Tsutsui²  Yoshinori Kinoshita³  Hiroki Fukunaga⁴  Masaru Murata⁴  Shunji Morita⁴  Rei Suzuki⁴  Nobuo Tanaka⁴  Masayuki Hiraki⁵ 

[1] Department of Diagnostic Pathology, Itami City Hospital, 1-100 Koyaike, 664-8540, Itami-shi, Hyogo, Japan;Department of Gastroenterology, Itami City Hospital, 1-100 Koyaike, 664-8540, Itami-shi, Hyogo, Japan;Department of Respiratory Medicine, Itami City Hospital, 1-100 Koyaike, 664-8540, Itami-shi, Hyogo, Japan;Department of Surgery, Itami City Hospital, 1-100 Koyaike, 664-8540, Itami-shi, Hyogo, Japan;Department of Surgery, Itami City Hospital, 1-100 Koyaike, 664-8540, Itami-shi, Hyogo, Japan;Department of Surgery, Kansai Rosai Hospital, Japan Organization of Occupational Health and Safety, 3-1-69 Inabaso, 660-8511, Amagasaki, Hyogo, Japan;

关键词: Clostridioides;    Fulminant colitis;    Proctocolectomy;    PCR-ribotype 027;    Helicobacter pylori;    Community-acquired CDI;   

DOI  :  10.1186/s40792-021-01220-9

来源: Springer

【 摘 要 】

BackgroundClostridioides (Clostridium) difficile infection (CDI) has become an increasingly significant disease not only as healthcare-associated infection, but also as community-acquired (CA) infection worldwide. CDI caused by the NAP1/BI/027 strain is reported to be more severe, difficult to cure, and frequently associated with recurrences in North America and Europe.Case presentationA 68-year-old woman was referred to our hospital for continuous lower abdominal pain 4 weeks after eradication therapy against Helicobacter pylori. While she was treated with fasting on the suspicion of ischemic colitis, she experienced septic shock. Emergent subtotal proctocolectomy revealed fulminant pseudomembranous C. difficile colitis. The C. difficile isolate recovered from the patient was identified as ribotype 027, which has been reported to be uncommon in Japan.ConclusionWe report a rare case of CA fulminant pseudomembranous colitis caused by ribotype 027 C. difficile after H. pylori eradication therapy.

【 授权许可】

CC BY