Applications of Nanobiomaterials in the Therapy and Imaging of Acute Liver Failure

Nano-Micro Letters

Shixian Lv¹  Hanze Hu²  Yu Tao³  Haixia Wang³  Yuanyuan Jin³  Ke Yi³  Mingqiang Li³ 

[1] Department of Bioengineering, University of Washington, 98195, Seattle, WA, USA;Department of Biomedical Engineering, Columbia University, 10027, New York, NY, USA;Laboratory of Biomaterials and Translational Medicine, The Third Affiliated Hospital, Sun Yat-sen University, 510630, Guangzhou, People’s Republic of China;

关键词: Acute liver failure;    Nanomaterials;    Drug/gene/cytokines delivery;    Targeted therapy;    Imaging;   

DOI  :  10.1007/s40820-020-00550-x

来源: Springer

【 摘 要 】

tsThis review focuses on the therapeutic mechanisms, targeting strategies of various nanomaterials in acute liver failure, and recent advances of diverse nanomaterials for acute liver failure therapy, diagnosis, and imaging.This review provides an outlook on the applications of nanomaterials, especially on the new horizons in acute liver failure therapy, and inspires broader interests across various disciplines.AbstractAcute liver failure (ALF), a fatal clinical disease featured with overwhelming hepatocyte necrosis, is a grand challenge in global health. However, a satisfactory therapeutic option for curing ALF is still absent, other than liver transplantation. Nanobiomaterials are currently being developed for the diagnosis and treatment of ALF. The liver can sequester most of nanoparticles from blood circulation, which becomes an intrinsic superiority for nanobiomaterials targeting hepatic diseases. Nanobiomaterials can enhance the bioavailability of free drugs, thereby significantly improving the therapeutic effects in ALF. Nanobiomaterials can also increase the liver accumulation of therapeutic agents and enable more effective targeting of the liver or specific liver cells. In addition, stimuli-responsive, optical, or magnetic nanomaterials exhibit great potential in the therapeutical, diagnostic, and imaging applications in ALF. Therefore, therapeutic agents in combination with nanobiomaterials increase the specificity of ALF therapy, diminish adverse systemic effects, and offer a multifunctional theranostic platform. Nanobiomaterial holds excellent significance and prospects in ALF theranostics. In this review, we summarize the therapeutic mechanisms and targeting strategies of various nanobiomaterials in ALF. We highlight recent developments of diverse nanomedicines for ALF therapy, diagnosis, and imaging. Furthermore, the challenges and future perspectives in the theranostics of ALF are also discussed.

【 授权许可】

CC BY