Tobacco use in the Myeloproliferative neoplasms: symptom burden, patient opinions, and care

BMC Cancer

Amylou C. Dueck¹  Gina L. Mazza¹  Holly L. Geyer²  Ruben A. Mesa³  Robyn M. Scherber⁴  Christen L. Andersen⁵  Sarah F. Christensen⁶  Hans C. Hasselbalch⁶  Nana Brochmann⁶ 

[1] Department of Health Sciences Research, Mayo Clinic, 13400 East Shea Boulevard, 85259, Scottsdale, AZ, USA;Department of Hematology and Medical Oncology, Mayo Clinic, 13400 East Shea Boulevard, 85259, Scottsdale, AZ, USA;Department of Hematology and Oncology, UT Health San Antonio MD Anderson Cancer Center, 7979 Wurzbach Rd, 78229, San Antonio, TX, USA;Department of Hematology and Oncology, UT Health San Antonio MD Anderson Cancer Center, 7979 Wurzbach Rd, 78229, San Antonio, TX, USA;Hematologic Malignancies, Incyte Corporation, Wilmington, Delaware, USA;Department of Hematology, University Hospital of Copenhagen at Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark;Department of Hematology, Zealand University Hospital, Roskilde, Vestermarksvej 9, 4000, Roskilde, Denmark;

关键词: Myeloproliferative neoplasms;    Cross-sectional internet-based survey;    Tobacco use;    Symptom burden;    Quality of life;   

DOI  :  10.1186/s12885-021-08439-7

来源: Springer

【 摘 要 】

BackgroundPatients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancies. The aim of this study was to analyze the association between smoking and MPN-related symptom burden and explore MPN patients’ opinions on smoking.MethodsA total of 435 patients with MPN participated in a cross-sectional internet-based survey developed by the Mayo Clinic and the Myeloproliferative Neoplasm Quality of Life Group. Patients reported their demographics, disease characteristics, tobacco use, and opinions on tobacco use. In addition, MPN-related symptoms were reported via the validated 10-item version of the Myeloproliferative Neoplasms Symptom Assessment Form.ResultsCurrent/former smokers reported worse fatigue (mean severity 5.6 vs. 5.0, p = 0.02) and inactivity (mean severity 4.0 vs. 3.4, p = 0.03) than never smokers. Moreover, current/former smokers more frequently experienced early satiety (68.5% vs. 58.3%, p = 0.03), inactivity (79.9% vs. 71.1%, p = 0.04), and concentration difficulties (82.1% vs. 73.1%, p = 0.04). Although not significant, a higher total symptom burden was observed for current/former smokers (mean 30.4 vs. 27.0, p = 0.07). Accordingly, overall quality of life was significantly better among never smokers than current/former smokers (mean 3.5 vs. 3.9, p = 0.03). Only 43.2% of the current/former smokers reported having discussed tobacco use with their physician, and 17.5% did not believe smoking increased the risk of thrombosis.ConclusionThe current study suggests that smoking may be associated with increased prevalence and severity of MPN symptoms and underscores the need to enhance patient education and address tobacco use in the care of MPN patients.

【 授权许可】

CC BY