Psychometric validation and refinement of the Interoception Sensory Questionnaire (ISQ) in adolescents and adults on the autism spectrum

Molecular Autism

Michelle Failla¹  Jacob I. Feldman²  Zachary J. Williams³  Tiffany G. Woynaroski⁴  Mark T. Wallace⁵  Ericka Wodka⁶  James S. Sutcliffe⁷  Evan Suzman⁸  Carissa J. Cascio⁹  Maria Niarchou^1,10 

[1] Center for Healthy Aging, Self Management and Complex Care, College of Nursing, The Ohio State University, Columbus, OH, USA;Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, 37232, Nashville, TN, USA;Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA;Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, 37232, Nashville, TN, USA;Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA;Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA;Medical Scientist Training Program, Vanderbilt University School of Medicine, Nashville, TN, USA;Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, 37232, Nashville, TN, USA;Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA;Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA;Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Hearing and Speech Sciences, Vanderbilt University Medical Center, 1215 21st Avenue South, Medical Center East, Room 8310, 37232, Nashville, TN, USA;Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA;Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA;Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Psychology, Vanderbilt University, Nashville, TN, USA;Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA;Center for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA;Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA;Graduate Program in Biomedical Sciences, Vanderbilt University, 1215 21st Avenue South, Medical Center East, Room 8310, 37232, Nashville, TN, USA;Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA;Frist Center for Autism and Innovation, Vanderbilt University, Nashville, TN, USA;Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, TN, USA;Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center, Nashville, TN, USA;Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA;

关键词: Autism;    Interoception;    Psychometric;    Reliability;    Validity;    Sensory;    Item response theory;    Measurement;   

DOI  :  10.1186/s13229-021-00440-y

来源: Springer

【 摘 要 】

BackgroundIndividuals on the autism spectrum are reported to display alterations in interoception, the sense of the internal state of the body. The Interoception Sensory Questionnaire (ISQ) is a 20-item self-report measure of interoception specifically intended to measure this construct in autistic people. The psychometrics of the ISQ, however, have not previously been evaluated in a large sample of autistic individuals.MethodsUsing confirmatory factor analysis, we evaluated the latent structure of the ISQ in a large online sample of adults on the autism spectrum and found that the unidimensional model fit the data poorly. Using misspecification analysis to identify areas of local misfit and item response theory to investigate the appropriateness of the seven-point response scale, we removed redundant items and collapsed the response options to put forth a novel eight-item, five-response choice ISQ.ResultsThe revised, five-response choice ISQ (ISQ-8) showed much improved fit while maintaining high internal reliability. Differential item functioning (DIF) analyses indicated that the items of the ISQ-8 were answered in comparable ways by autistic adolescents and adults and across multiple other sociodemographic groups.LimitationsOur results were limited by the fact that we did not collect data for typically developing controls, preventing the analysis of DIF by diagnostic status. Additionally, while this study proposes a new 5-response scale for the ISQ-8, our data were not collected using this method; thus, the psychometric properties for the revised version of this instrument require further investigation.ConclusionThe ISQ-8 shows promise as a reliable and valid measure of interoception in adolescents and adults on the autism spectrum, but additional work is needed to examine its psychometrics in this population. A free online score calculator has been created to facilitate the use of ISQ-8 latent trait scores for further studies of autistic adolescents and adults (available at https://asdmeasures.shinyapps.io/ISQ_score/).

【 授权许可】

CC BY