Surfactant protein D: a useful marker for differentiation of drug-induced pneumonia and bacterial pneumonia

Pneumonia

Hazuki Takato¹  Yukari Ichikawa²  Satoshi Watanabe³  Kazuo Kasahara³  Masahide Yasui⁴  Hiroshi Ueda⁵  Tamotsu Ishizuka⁶  Miho Mitsui⁶  Toshihiro Takeda⁶  Makiko Yamaguchi⁶  Kousuke Kurokawa⁶  Ryo Chikazawa⁶  Yukihiro Umeda⁶  Masaki Anzai⁶  Tomoaki Sonoda⁶  Yuko Waseda⁷ 

[1] Department of Respiratory Medicine, Japan Community Health Care Organisation Kanazawa Hospital, Kanazawa, Japan;Department of Respiratory Medicine, Kanazawa Municipal Hospital, Kanazawa, Japan;Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;Department of Respiratory Medicine, National Hospital Organisation Nanao National Hospital, Gifu, Japan;Department of Surgery, Houju Memorial Hospital, Nomi, Japan;Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, 910-1193, Eiheiji, Fukui, Japan;Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, 910-1193, Eiheiji, Fukui, Japan;Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan;Department of Surgery, Houju Memorial Hospital, Nomi, Japan;

关键词: Surfactant protein D;    Drug-induced pneumonia;    Bacterial pneumonia;    Krebs von den Lungen-6;    Surfactant protein A;   

DOI  :  10.1186/s41479-021-00087-6

来源: Springer

【 摘 要 】

BackgroundDrug-induced pneumonia (d-pneumonia) and bacterial pneumonia (b-pneumonia) are often difficult to differentiate; therefore, this study examined the possibility of differentiating them using serum biomarkers.MethodsThe study included 22 and 16 patients diagnosed with b- and d-pneumonia, respectively, at our institution or affiliated institutions. For d-pneumonia, the causative drug was minocycline hydrochloride in four patients, gefitinib in two patients, nivolumab in two patients, pembrolizumab in two patients, sulfasalazine in two patients, loxoprofen in one patient, Bouiougitou in one patient, edoxaban tosilate hydrate in one patient, and abemaciclib in one patient. White blood cell (WBC), C-reactive protein (CRP), Krebs von den Lungen-6 (KL-6), surfactant protein (SP)-D, and SP-A levels were measured in each patient and compared between the groups.ResultsSignificant differences were noted in the WBC and SP-D levels between the two groups (P < 0.05, P < 0.001), but not in the CRP, KL-6, or SP-A levels.ConclusionThe study results suggest that SP-D is a useful marker for differentiating b-pneumonia and d-pneumonia.

【 授权许可】

CC BY