Prevalence of diabetes and hypertension and their interaction effects on cardio-cerebrovascular diseases: a cross-sectional study

BMC Public Health

Zhehui Wang¹  Tubao Yang¹  Hanlin Fu² 

[1] Department of Epidemiology and Health Statistics, XiangYa School of Public Health, Central South University, Changsha, Hunan Province, China;Hunan Provincial Key Laboratory of Clinical Epidemiology, Changsha, China;Department of Obstetrics and Gynecology, The First Affiliated Hospital of Zhengzhou University, 450052, Zhengzhou, China;

关键词: Diabetes;    Hypertension;    Stroke;    Coronary heart disease;    Interaction;   

DOI  :  10.1186/s12889-021-11122-y

来源: Springer

【 摘 要 】

BackgroundHypertension and diabetes mellitus are two of the major risk factors for cardio-cerebrovascular diseases (CVDs). Although prior studies have confirmed that the coexistence of the two can markedly increase the risk of CVDs, few studies investigated whether potential interaction effects of hypertension and diabetes can result in greater cardio-cerebrovascular damage. We aimed to investigate the prevalence of hypertension and diabetes and whether they both affect synergistically the risk of CVDs.MethodsA cross-sectional study was conducted by using a multistage stratified random sampling among communities in Changsha City, Hunan Province. Study participants aged > = 18 years were asked to complete questionnaires and physical examinations. Multivariate logistic regression models were performed to evaluate the association of diabetes, hypertension, and their multiplicative interaction with CVDs with adjustment for potential confounders. We also evaluated additive interaction with the relative excess risk ratio (RERI), attribution percentage (AP), synergy index (SI).ResultsA total of 14,422 participants aged 18–98 years were collected (men = 5827, 40.7%). The prevalence was 22.7% for hypertension, 7.0% for diabetes, and 3.8% for diabetes with hypertension complication, respectively. Older age, women, higher educational level, unmarried status, obesity (central obesity) were associated with increased risk of hypertension and diabetes. We did not find significant multiplicative interaction of diabetes and hypertension on CVDs, but observed a synergistic additive interaction on coronary heart disease (SI, 1.43; 95% CI, 1.03–1.97; RERI, 1.94; 95% CI, 0.05–3.83; AP, 0.26; 95% CI, 0.06–0.46).ConclusionsDiabetes and hypertension were found to be associated with a significantly increased risk of CVDs and a significant synergistic additive interaction of diabetes and hypertension on coronary heart disease was observed. Participants who were old, women, highly educated, unmarried, obese (central obese) had increased risk of diabetes and hypertension.

【 授权许可】

CC BY