Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Cancer Cell International

Jieyu He¹  Zhongyue Liu²  Lu Wan²  Lin Ling²  Chao Tu³  Zhihong Li³  Xiaolei Ren³ 

[1] Department of Geriatrics, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;Department of Orthopedics, The Second Xiangya Hospital, Central South University, No 139 Middle Renmin Road, 410011, Changsha, Hunan, China;Department of Orthopedics, The Second Xiangya Hospital, Central South University, No 139 Middle Renmin Road, 410011, Changsha, Hunan, China;Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, 410011, Changsha, Hunan, China;

关键词: LncRNA;    Wnt;    β-catenin;    Osteosarcoma;    Drug resistance;    Stemness;   

DOI  :  10.1186/s12935-021-02013-8

来源: Springer

【 摘 要 】

Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

【 授权许可】

CC BY