COVID-19 Dynamics: A Heterogeneous Model

Frontiers in Public Health

Andrey Gerasimov¹  Irina Semenycheva¹  Mikhail Lebedev²  Georgy Lebedev³ 

[1] Department of Information and Internet Technology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia;Department of Information and Internet Technology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia;Center for Bioelectric Interfaces, Institute of Cognitive Neuroscience, National Research University Higher School of Economics, Moscow, Russia;Department of Information and Internet Technology, I.M. Sechenov First Moscow State Medical University, Moscow, Russia;Federal Research Institute for Health Organization and Informatics, Moscow, Russia;

关键词: COVID 19;    dynamical model;    epidemic;    quarantine;    antiepidemic measures;    population immunity;   

DOI  :  10.3389/fpubh.2020.558368

来源: Frontiers

【 摘 要 】

The mathematical model reported here describes the dynamics of the ongoing coronavirus disease 2019 (COVID-19) epidemic, which is different in many aspects from the previous severe acute respiratory syndrome (SARS) epidemic. We developed this model when the COVID-19 epidemic was at its early phase. We reasoned that, with our model, the effects of different measures could be assessed for infection control. Unlike the homogeneous models, our model accounts for human population heterogeneity, where subpopulations (e.g., age groups) have different infection risks. The heterogeneous model estimates several characteristics of the epidemic more accurately compared to the homogeneous models. According to our analysis, the total number of infections and their peak number are lower compared to the assessment with the homogeneous models. Furthermore, the early-stage infection increase is little changed when population heterogeneity is considered, whereas the late-stage infection decrease slows. The model predicts that the anti-epidemic measures, like the ones undertaken in China and the rest of the world, decrease the basic reproductive number but do not result in the development of a sufficient collective immunity, which poses a risk of a second wave. More recent developments confirmed our conclusion that the epidemic has a high likelihood to restart after the quarantine measures are lifted.

【 授权许可】

CC BY