Carriage Dynamics of Pneumococcal Serotypes in Naturally Colonized Infants in a Rural African Setting During the First Year of Life

Frontiers in Pediatrics

Michael R. Barer¹  Robert F. Breiman²  Keith P. Klugman³  Archibald Worwui⁴  Rowan E. Bancroft⁴  Madikay Senghore⁴  Ebenezer Foster-Nyarko⁴  Chinelo Ebruke⁴  Peggy-Estelle Tientcheu⁴  Fatima Ceesay⁴  Catherine Okoi⁴  Ebrima Bojang⁴  Brenda A. Kwambana-Adams⁵  Richard A. Adegbola⁶  Martin Antonio⁷  Stephanie W. Lo⁸  Rebecca A. Gladstone⁸  Chrispin Chaguza⁹  Stephen D. Bentley^1,10  Lesley McGee^1,11 

[1] Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom;Emory Global Health Institute, Emory University, Atlanta, GA, United States;Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, United States;Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia;Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia;NIHR Global Health Research Unit on Mucosal Pathogens, Division of Infection and Immunity, University College London, London, United Kingdom;Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia;RAMBICON Immunisation & Global Health Consulting, Lekki, Nigeria;Medical Research Council (MRC) Unit The Gambia at the London School of Hygiene and Tropical Medicine, Fajara, Gambia;Warwick Medical School, University of Warwick, Coventry, United Kingdom;Parasites and Microbes Programme, Wellcome Sanger Institute, Cambridge, United Kingdom;Parasites and Microbes Programme, Wellcome Sanger Institute, Cambridge, United Kingdom;Darwin College, University of Cambridge, Cambridge, United Kingdom;Parasites and Microbes Programme, Wellcome Sanger Institute, Cambridge, United Kingdom;Department of Pathology, University of Cambridge, Cambridge, United Kingdom;Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA, United States;

关键词: pneumococcus;    serotype;    carriage duration;    acquisition;    Africa;    infants;   

DOI  :  10.3389/fped.2020.587730

来源: Frontiers

【 摘 要 】

Streptococcus pneumoniae (the pneumococcus) carriage precedes invasive disease and influences population-wide strain dynamics, but limited data exist on temporal carriage patterns of serotypes due to the prohibitive costs of longitudinal studies. Here, we report carriage prevalence, clearance and acquisition rates of pneumococcal serotypes sampled from newborn infants bi-weekly from weeks 1 to 27, and then bi-monthly from weeks 35 to 52 in the Gambia. We used sweep latex agglutination and whole genome sequencing to serotype the isolates. We show rapid pneumococcal acquisition with nearly 31% of the infants colonized by the end of first week after birth and quickly exceeding 95% after 2 months. Co-colonization with multiple serotypes was consistently observed in over 40% of the infants at each sampling point during the first year of life. Overall, the mean acquisition time and carriage duration regardless of serotype was 38 and 24 days, respectively, but varied considerably between serotypes comparable to observations from other regions. Our data will inform disease prevention and control measures including providing baseline data for parameterising infectious disease mathematical models including those assessing the impact of clinical interventions such as pneumococcal conjugate vaccines.

【 授权许可】

CC BY