Heterogeneous Klebsiella pneumoniae Co-infections Complicate Personalized Bacteriophage Therapy

Frontiers in Cellular and Infection Microbiology

Zhenquan Wei¹  Qin Huang²  Shanke Ye²  Hongzhou Lu²  Zhaoqin Zhu³  Jinfeng Cai³  Xin Shi⁴  Jinhong Qin⁵  Lisha Li⁶  Jianzhong Zhang⁷  Jingyan Weng⁷  Juan Bao⁸  Wei Zhao⁹  Hongyu Ou^1,10  Demeng Tan^1,11  Yejing Shi^1,11  Chunlan Hu^1,11  Nannan Wu^1,11  Mingquan Guo^1,12  Tongyu Zhu^1,13  Xiaokui Guo^1,14 

[1] Core Facility of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Department of Laboratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Microbiology and Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China;Department of Microbiology, School of Basic Medical Science, Guizhou Medical University, Guiyang, China;Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China;Department of Urology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Experiment Teaching Center of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China;School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China;Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Department of Laboratory Medicine, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Department of Urology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China;Shanghai Institute of Phage, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China;

关键词: urinary tract infection;    phage therapy;    percutaneous nephrostomy;    heterogeneous cells;    Klebsiella pneumoniae;   

DOI  :  10.3389/fcimb.2020.608402

来源: Frontiers

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